N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine

Base Information

• Chemical Name: N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine
• CAS No.: 885673-43-8
• Molecular Formula: C₂₄H₂₅ClN₂O₂
• Molecular Weight: 408.928
• Mol file: 885673-43-8.mol

Synonyms:N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine

Chemical Property of N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine

There total 4 articles about N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-(dimethylamino)-1-(4-chlorobenzene)-1-propanol (16254-21-0) + biphenyl-4-carboxylic acid (92-92-2) → N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine (885673-43-8)

Guidance literature:

biphenyl-4-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 1h; Heating / reflux;

3-(dimethylamino)-1-(4-chlorobenzene)-1-propanol; In tetrahydrofuran; toluene; at 20 ℃; for 18h;

Reference yield:

1-(4-chlorophenyl)-3-dimethylamino-1-propanone (2138-38-7) → N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine (885673-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

2: 280 mg / tetrahydrofuran / 18 h / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm051121i

Reference yield:

biphenyl-4-carboxylic acid (92-92-2) → N-[1-(4-chlorophenyl)-3-dimethylaminopropyloxycarbonyl]-4-phenyl-phenylamine (885673-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylphosphoryl azide; Et₃N / toluene / 1 h / Heating

2: 280 mg / tetrahydrofuran / 18 h / 20 °C

With diphenylphosphoranyl azide; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/jm051121i

upstream raw materials:

3-(dimethylamino)-1-(4-chlorobenzene)-1-propanol

4-biphenyl isocyanate

1-(4-chlorophenyl)-3-dimethylamino-1-propanone

biphenyl-4-carboxylic acid

Refernces

• 1、 -. "UII-MODULATING COMPOUNDS AND THEIR USE". Page/Page column 58-59. . Retrieved 2010/11/25.