dimethoxypropiophenone 4-methylphenylsulfonylhydrazone

Base Information

• Chemical Name: dimethoxypropiophenone 4-methylphenylsulfonylhydrazone
• CAS No.: 1449676-66-7
• Molecular Formula: C₁₈H₂₂N₂O₄S
• Molecular Weight: 362.45
• Mol file: 1449676-66-7.mol

Synonyms:dimethoxypropiophenone 4-methylphenylsulfonylhydrazone

Chemical Property of dimethoxypropiophenone 4-methylphenylsulfonylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethoxypropiophenone 4-methylphenylsulfonylhydrazone

There total 1 articles about dimethoxypropiophenone 4-methylphenylsulfonylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethoxypropiophenone (831-00-5) + toluene-4-sulfonic acid hydrazide (1576-35-8) → dimethoxypropiophenone 4-methylphenylsulfonylhydrazone (1449676-66-7)

Guidance literature:

In methanol; at 60 ℃;

DOI:10.1021/jo401217x

Reference yield: 100.0%

2-nitrophenyl bromide (577-19-5) + dimethoxypropiophenone 4-methylphenylsulfonylhydrazone (1449676-66-7) → 1-nitro-2-[1-(2,4-dimethoxyphenyl)-1-propen-1-yl]benzene

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tet.2021.132331

Reference yield: 82.0%

2-nitrophenyl bromide (577-19-5) + dimethoxypropiophenone 4-methylphenylsulfonylhydrazone (1449676-66-7) → 3-(2,4-dimethoxyphenyl)-2-methyl-1H-indole

Guidance literature:

2-nitrophenyl bromide; dimethoxypropiophenone 4-methylphenylsulfonylhydrazone; With bis-triphenylphosphine-palladium(II) chloride; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 8h; Inert atmosphere;

With carbon monoxide; 1,3-bis-(diphenylphosphino)propane; In 1,4-dioxane; at 140 ℃; for 72h; under 4560.31 Torr; Inert atmosphere;

DOI:10.1016/j.tet.2021.132331

upstream raw materials:

2,4-dimethoxypropiophenone

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

1-(1-(2,4-dimethoxyphenyl)prop-1-en-1-yl)-1H-indole-4-carbonitrile

1-(1-(2,4-dimethoxyphenyl)prop-1-en-1-yl)-1H-indole-4-carbonitrile

(Z)-2,4-dimethoxy-1-(1-(4-methoxyphenyl)prop-1-en-1-yl)benzene

Refernces

• 1、 Roche, Maxime,Frison, Gilles,Brion, Jean-Daniel,Provot, Olivier,Hamze, Abdallah,Alami, Mouad. "Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N -tosylhydrazones and indole derivatives". . p. 8485 - 8495. Retrieved 2013/09/24.