Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-

Base Information

• Chemical Name: Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-
• CAS No.: 57-85-2
• Molecular Formula: C22H32O3
• Molecular Weight: 344.494
• Hs Code.: 29372900
• Mol file: 57-85-2.mol

Synonyms:Testex;Primotestone;Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17.beta.)-;17.beta.-(Propionyloxy)androst-4-en-3-one;.DELTA.4-androstene-17.beta.-propionate-3-one;17.beta.-hydroxyandrost-4-en-3-one, propionate;3-Oxoandrost-4-en-17-yl propionate, (17.beta.)-;Androst-4-en-3-one, 17.beta.-hydroxy-, propionate;17-(1-Oxopropoxy)androst-4-en-3-one, (17.beta.)-;PDMMFKSKQVNJMI-QUUHFIRTSA-N

Chemical Property of Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-

Chemical Property:

• Appearance/Colour: white or yellowish-white crystals or a white or creamy-white crystalline powder
• Vapor Pressure: 1.89E-08mmHg at 25°C
• Melting Point: 118-123 °C
• Refractive Index: 1.537
• Boiling Point: 454.6 °C at 760 mmHg
• Flash Point: 196.3 °C
• PSA: 43.37000
• Density: 1.1 g/cm³
• LogP: 4.84010
• Solubility.: ethanol: 10 mg/mL
• Water Solubility.: <0.1 g/100 mL at 24.5℃
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 344.23514488
• Heavy Atom Count: 25
• Complexity: 621

Purity/Quality:

99% ^*data from raw suppliers

Testosterone propionate solid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 45-22-63
• Safety Statements: 53-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
• Isomeric SMILES: CCC(=O)O[C@H]1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
• Uses: Testosterone propionate is an is an androgen and anabolic steroid (AAS) medication, which directs the development of the male phenotype during embryogenesis and at puberty. It has been widely used by athletes and bodybuilders for physical performance enhancement. Testosterone propionate has also been used for studying its effects on pregnant ewes.

Technology Process of Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-

There total 18 articles about Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

propionyl chloride (79-03-8) + 3,3-(ethylenedioxy)-5-androsten-17β-ol (975-57-5) → testosterone propionate (57-85-2)

Guidance literature:

propionyl chloride; 3,3-(ethylenedioxy)-5-androsten-17β-ol; With pyridine; dmap; In 1,2-dichloro-ethane; at 30 ℃; Inert atmosphere;

With hydrogenchloride; In water;

Reference yield: 97.36%

propionic acid (802294-64-0,79-09-4) + 17β-hydroxy-3-methoxyandrosta-3,5-diene → testosterone propionate (57-85-2)

Guidance literature:

propionic acid; 17β-hydroxy-3-methoxyandrosta-3,5-diene; With diisopropyl-carbodiimide; In dichloromethane; at 5 ℃; Inert atmosphere;

With hydrogenchloride; In water;

Reference yield: 89.0%

(8S,9S,10R,13S,14S,17S)-4,5-dibromo-10,13-dimethyl-3-oxohexadecahydro-1Hcyclopenta[a]phenanthren-17-yl propionate → testosterone propionate (57-85-2)

Guidance literature:

With 1,1'-bis(trimethylsilyl)-1,1',4,4'-tetrahydro-4,4'-bipyridylidene; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c7cc07377a

upstream raw materials:

androsten-(4)-yl-(17β)-propionate

3-acetoxy-17β-(1-oxopropoxy)-androsta-3,5-diene

17β-propionyloxy-androst-5-en-3β-ol

testosterone

Downstream raw materials:

3-benzyloxy-17β-propionyloxy-androsta-3,5-diene

2-Benzyloxy-Δ^1,4-androstadien-ol-(17β)-on-(3)-acetat

4-Chlor-testosteron-propionat

5-oxo-A-nor-3,5-seco-17β-hydroxy-androstan-3-oic acid

Refernces

• 1、 -. "Synthesis method of alkyl acid testosterone". . . Retrieved 2020/12/10.
• 2、 -. "NEW ENZYMATIC PROCESS FOR THE PREPARATION OF TESTOSTERONE AND ESTERS THEREOF". Paragraph 0146; 0147; 0148; 0149; 0150; 0151. . Retrieved 2017/02/28.