L-Histidine hydrochloride

Base Information

• Chemical Name: L-Histidine hydrochloride
• CAS No.: 645-35-2
• Molecular Formula: C6H9N3O2^.HCl
• Molecular Weight: 191.617
• Hs Code.: 2922499990
• European Community (EC) Number: 211-438-9,213-754-2
• UNII: 1D5Q932XM6
• DSSTox Substance ID: DTXSID3020700
• NCI Thesaurus Code: C87704
• RXCUI: 1309689
• ChEMBL ID: CHEMBL1256578
• Mol file: 645-35-2.mol

Synonyms:L-Histidine hydrochloride;645-35-2;1007-42-7;(S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride;H-His-OH.xHCl;Histidine monohydrochloride;Histidine HCl;L-Histidine HCl;l-Histidine.HCl;L-Histidine, monohydrochloride;Histidine, hydrochloride;Histidine hydrochloride;L-Histidine hydrochloride (VAN);Histidine-L-HCl;L-Histidine, hydrochloride (1:1);Histidine hydrochloride, L-;Histidine hydrochloride (VAN);(-)-Histidine monohydrochloride;EINECS 211-438-9;Histidine monohydrochloride, L-(+)-;NSC 257867;L-Hisidine monohydrocholoride;UNII-1D5Q932XM6;AI3-18473;DTXSID3020700;Histidine monohydrochloride [NF];(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid hydrochloride;1D5Q932XM6;EINECS 213-754-2;L-Histidine, monohydrochloride, hydrate;NCGC00093950-01;(2S)-2-Amino-3-(1H-imidazol-4-yl)-propanoic acid hydrochloride;(S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid HCl;H-His-OH.HCl.H2O;C6H9N3O2.xClH;Histidine, hydrochloride (1:1);Histidine, monohydrochloride, DL-;(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;hydrochloride;EINECS 229-266-8;Histidine, hydrochloride, L-;NSC 206275;C6-H9-N3-O2.x-Cl-H;H-His-OH.HCl;Histidine, monohydrochloride;C6H9N3O2.ClH;NSC-257867;CCRIS 7814;C6-H9-N3-O2.Cl-H;PHOTONYL;(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride;Histidine Hydrochloride(L);propanoic acid hydrochloride;SUNACTYL LS 9610;HISTIDINE HCL [INCI];OSMHYDRAN LS 8453;DTXCID70700;L- histidine monohydrochloride;SCHEMBL209483;L-Histidine Hydrochloride,(S);P.P.A.A.;CHEMBL1256578;Histidine, monohydrochloride, L-;Tox21_111234;Tox21_500566;MFCD00064556;AKOS015898038;L-Histidine HCl (H-L-His-OH.HCl);CCG-221870;DS-6380;FD20036;LP00566;(S)-2-amino-3-(1H-imidazol-4-yl);HISTIDINE HYDROCHLORIDE [WHO-DD];HISTIDINE, L-, MONOHYDROCHLORIDE;NCGC00261251-01;CAS-645-35-2;LS-75853;HISTIDINE MONOHYDROCHLORIDE ANHYDROUS;LS-194121;CS-0009863;EU-0100566;H0150;EN300-74584;H 8125;A867866;A929240;SR-01000075269;J-521646;SR-01000075269-1;Q27252266;L-alpha-Amino-4(or 5)-imidazolepropionic Acid Monohydrochloride;S(+)-alpha-Amino-1H-imidazole-4-propanoic acid hydrochloride;70605-39-9

Chemical Property of L-Histidine hydrochloride

Chemical Property:

• Vapor Pressure: 3.25E-09mmHg at 25°C
• Melting Point: 243-244 °C(Solv: ethanol (64-17-5))
• Boiling Point: 458.9 °C at 760 mmHg
• Flash Point: 231.3 °C
• PSA: 92.00000
• Density: 1.472[at 20℃]
• LogP: 0.86640
• Storage Temp.: 2-8°C
• Water Solubility.: 149.55g/L at 20℃
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 191.0461543
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

99% ^*data from raw suppliers

L-Histidine hydrochloride solution 100?mMaminoacidin0.1MHCl,analyticalstandard ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C1=C(NC=N1)CC(C(=O)O)N.Cl
• Isomeric SMILES: C1=C(NC=N1)C[C@@H](C(=O)O)N.Cl
• Recent EU Clinical Trials: A Phase II/III randomized, double-blind, placebo-controlled, cognitive endpoint, multicenter study of potential disease modifying therapies in individuals at risk for and with dominantly inherited Alzheimer's disease (DIAD)
• Description: L-Histidine hydrochloride can undergo racemization due to heating in water, leading to the formation of DL-histidine. It can be used as a supplement in conditions of riboflavin vitamin deficiency.
• Uses: Amino acid.

Technology Process of L-Histidine hydrochloride

There total 5 articles about L-Histidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-histidine (71-00-1,26062-48-6,90081-11-1) → L-histidine monohydrochloride (645-35-2)

Guidance literature:

With hydrogenchloride; ¹⁸O-labeled water; In 1,4-dioxane; at 100 ℃; for 48h; Sealed tube;

Reference yield: 30.0%

histidine hydrochloride (6459-59-2) → L-histidine monohydrochloride (645-35-2)

Guidance literature:

DOI:10.1021/ja00240a052

Reference yield:

histidine hydrochloride (6459-59-2) → L-histidine monohydrochloride (645-35-2) + D-histidine monohydrochloride (6341-24-8)

Guidance literature:

With poly-(p-acrylamido-(S)-phenylalanine); In water; at 25 ℃; for 8h; Product distribution; var. polymer, time;

upstream raw materials:

histidine hydrochloride

L-histidine

L-histidine

Downstream raw materials:

2,5-diiodo-L-histidine ; hydrochloride

histidine hydrochloride

(2S)-2-amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid

4-cyanomethylimidazole

Refernces

• 1、 -. "Application of isotope-enriched 3-amino-1-propanesulfonic acid and derivative thereof". Paragraph 0224-0225. . Retrieved 2021/05/15.
• 2、 Shimon, L. J. W.,Zbaida, D.,Addadi, L.,Leiserowitz, L.,Lahav, M.. "DESIGN OF STEREOSPECIFIC INHIBITORS FOR CRYSTAL DISSOLUTION". . p. 199 - 222. Retrieved 2007/10/02.