1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol

Base Information

• Chemical Name: 1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol
• CAS No.: 145661-52-5
• Molecular Formula: C₁₃H₂₀O₅
• Molecular Weight: 256.299
• Mol file: 145661-52-5.mol

Synonyms:1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol

Chemical Property of 1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol

There total 2 articles about 1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-2-(2-ethyl)dioxolane (18742-02-4) + 4,4-dimethoxycyclohexa-2,5-dienone (935-50-2) → 1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol (145661-52-5)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) THF, 2.) -78 deg C, 30 min;

DOI:10.1039/p19960001385

Reference yield:

4,4-dimethoxycyclohexa-2,5-dienone (935-50-2) + 1,3-dioxolan-2-ylethylmagnesium bromide (37610-80-3) → 1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol (145661-52-5)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1039/c39920001589

Reference yield:

1-(2-[1,3]Dioxolan-2-yl-ethyl)-4,4-dimethoxy-cyclohexa-2,5-dienol (145661-52-5) → 4-<2-(1,3-Dioxolan-2-yl)ethyl>-4-hydroxycyclohexa-2,5-dien-1-one (145661-53-6)

Guidance literature:

With oxalic acid; silica gel; In dichloromethane; Yield given;

DOI:10.1039/c39920001589

upstream raw materials:

4,4-dimethoxycyclohexa-2,5-dienone

1,3-dioxolan-2-ylethylmagnesium bromide

2-bromo-2-(2-ethyl)dioxolane

Downstream raw materials:

4-<2-(1,3-Dioxolan-2-yl)ethyl>-4-hydroxycyclohexa-2,5-dien-1-one

Refernces

• 1、 McKillop, Alexander,McLaren, Lee,Taylor, Richard J. K.,Watson, Robert J.,Lewis, Norman J.. "The total synthesis of the diepoxycyclohexanone antibiotic aranorosin and novel synthetic analogues". . p. 1385 - 1393. Retrieved 2007/10/03.