Technology Process of 1-benzyloxy-2-bromo-5-methyl-4-[4-[2-(methoxymethoxy)ethyl]benzyl]benzene
There total 10 articles about 1-benzyloxy-2-bromo-5-methyl-4-[4-[2-(methoxymethoxy)ethyl]benzyl]benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylsilane; boron trifluoride diethyl etherate;
In
acetonitrile;
at 0 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Oxone; sodium bromide / water / 2.5 h / 20 °C
2.1: potassium hydroxide; sodium hypochlorite / water / 1 h / 120 °C
3.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 1 h / 120 °C
4.1: triethylamine / chloroform / 1 h / 0 - 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 °C
6.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
6.2: 1.5 h / -78 °C
7.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 0.25 h / 0 °C
With
triethylsilane; Oxone; potassium hydroxide; sodium hypochlorite; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; triethylamine; sodium bromide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane; chloroform; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 1 h / 120 °C
2.1: triethylamine / chloroform / 1 h / 0 - 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
4.2: 1.5 h / -78 °C
5.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 0.25 h / 0 °C
With
triethylsilane; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; triethylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane; chloroform; acetonitrile;