N-(4-Amino-2,5-dimethoxyphenyl)benzamide

Base Information

• Chemical Name: N-(4-Amino-2,5-dimethoxyphenyl)benzamide
• CAS No.: 6268-05-9
• Molecular Formula: C15H16N2O3
• Molecular Weight: 272.304
• European Community (EC) Number: 228-441-6
• NSC Number: 50201,37139
• UNII: 230CS62TQ0
• DSSTox Substance ID: DTXSID4064187
• Nikkaji Number: J211.500J
• Wikidata: Q81991322
• Mol file: 6268-05-9.mol

Synonyms:6268-05-9;N-(4-Amino-2,5-dimethoxyphenyl)benzamide;Fast Blue RR;4-Benzamido-2,5-dimethoxyaniline;Fast Blue RR Base;4'-Amino-2',5'-dimethoxybenzanilide;Neutrosel Blue R;Fast Navy DR;Blue Salt NRR;Sanyo Fast Blue RR Base;Fast Blue MR Base;Fast Blue Salt RR;Daito Blue Base RR;Daito Blue Salt RR;Mitsui Blue RR Salt;4-Benzoylamino-2,5-dimethoxyaniline;Sanyo Fast Blue Salt RR;Fast Red PDC;Azoene Fast Blue RR Base;Azoene Fast Blue RR Salt;Fast Blue Base RR;Hiltonil Fast Blue RR Base;Diazo Fast Blue RR;Benzamide, N-(4-amino-2,5-dimethoxyphenyl)-;2,5-Dimethoxy-4-(benzoylamino)aniline;C.I. Azoic Diazo Component 24;Azoic Diazo Component 24 (Base);Benzanilide, 4'-amino-2',5'-dimethoxy-;C.I. 37155;230CS62TQ0;NSC 37139;NSC 50201;NSC-37139;NSC-50201;Benzamide,N-(4-amino-2,5-dimethoxyphenyl)-;Benzanilide,5'-dimethoxy-;Benzamide,5-dimethoxyphenyl)-;MFCD00008369;Oprea1_095782;SCHEMBL592866;UNII-230CS62TQ0;DTXSID4064187;DDRCIGNRLHTTIW-UHFFFAOYSA-;NSC37139;NSC50201;EINECS 228-441-6;2,5-Dimethoxy-4-benzoylaminoaniline;AKOS000120749;BS-49311;CI 37155;A1241;CS-0331564;FT-0636052;N-(4-Amino-2,5-dimethoxyphenyl)benzamide #;E78207;A922921;4-AMINO-1-(BENZOYLAMINO)-3,6-DIMETHOXYBENZENE;5-AMINO-2-(BENZOYLAMINO)-1,4-DIMETHOXYBENZENE;Z104484848

Chemical Property of N-(4-Amino-2,5-dimethoxyphenyl)benzamide

Chemical Property:

• Appearance/Colour: purple-brown powder
• Vapor Pressure: 6.38E-06mmHg at 25°C
• Melting Point: 165-168 °C
• Refractive Index: 1.636
• Boiling Point: 378.2 °C at 760 mmHg
• PKA: 12.05±0.70(Predicted)
• Flash Point: 182.5 °C
• PSA: 73.58000
• Density: 1.245 g/cm³
• LogP: 3.19250
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 272.11609238
• Heavy Atom Count: 20
• Complexity: 318

Purity/Quality:

99% ^*data from raw suppliers

Azoic Diazo Component 24 (Base) >97.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1N)OC)NC(=O)C2=CC=CC=C2
• Uses: N-(4-Amino-2,5-dimethoxyphenyl)benzamide is used in preparation of Indazoles that inhibit one or more receptor, or non-receptor, tyrosine or serine/threonine kinase.

Technology Process of N-(4-Amino-2,5-dimethoxyphenyl)benzamide

There total 2 articles about N-(4-Amino-2,5-dimethoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(2,5-Dimethoxy-4-nitrophenyl)benzamide (92-20-6) → N-(4-Amino-2,5-dimethoxyphenyl)benzamide (6268-05-9)

Guidance literature:

With hydrogenchloride; tin; In ethanol; for 3h; Heating;

DOI:10.1039/a907633f

Reference yield:

N-(2,5-Dimethoxyphenyl)benzamide (135-45-5) → N-(4-Amino-2,5-dimethoxyphenyl)benzamide (6268-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / HNO₃; H₂O / acetic acid / 1.5 h / 20 °C

2: 89 percent / tin; HCl / aq. ethanol / 3 h / Heating

With hydrogenchloride; tin; water; nitric acid; In ethanol; acetic acid; 1: Nitration / 2: Reduction;

DOI:10.1039/a907633f

Reference yield: 90.0%

N-(4-Amino-2,5-dimethoxyphenyl)benzamide (6268-05-9) + p-toluenesulfonyl chloride (98-59-9) → N-[2,5-Dimethoxy-4-(p-tolylsulfonylamino)phenyl]benzamide (262436-48-6)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1039/a907633f

upstream raw materials:

N-(2,5-Dimethoxy-4-nitrophenyl)benzamide

N-(2,5-Dimethoxyphenyl)benzamide

Downstream raw materials:

4-benzoylamino-2,5-dimethoxy-benzenediazonium-betaine

N-(2,5-Dimethoxy-4-methylamino-phenyl)-benzamide

N-[2,5-Dimethoxy-4-(p-tolylsulfonylamino)phenyl]benzamide

N-[4-(2-azido-acetylamino)-2,5-dimethoxy-phenyl]-benzamide

Refernces