(17beta)-4-iodo-3-oxoandrostan-17-yl 4-methylpyridine-3-carboxylate

Base Information

• Chemical Name: (17beta)-4-iodo-3-oxoandrostan-17-yl 4-methylpyridine-3-carboxylate
• CAS No.: 89648-35-1
• Molecular Formula: C₂₆H₃₄NO₃*I
• Molecular Weight: 535.465
• Mol file: 89648-35-1.mol

Synonyms:

Chemical Property of (17beta)-4-iodo-3-oxoandrostan-17-yl 4-methylpyridine-3-carboxylate

Chemical Property:

• Vapor Pressure: 5.76E-13mmHg at 25°C
• Boiling Point: 569.1°C at 760 mmHg
• Flash Point: 298°C
• Density: 1.43g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (17beta)-4-iodo-3-oxoandrostan-17-yl 4-methylpyridine-3-carboxylate

There total 4 articles about (17beta)-4-iodo-3-oxoandrostan-17-yl 4-methylpyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

androst-4-en-3-on-17β-yl nicotinate (668-56-4) + methyl iodide (74-88-4) → 17β-<(1-methyl-3-pyridiniumcarbonyl)oxy>androst-4-en-3-one iodide (89648-35-1)

Guidance literature:

In acetone; Heating;

DOI:10.1002/jps.2600730324

Reference yield:

nicotinic acid (59-67-6) → 17β-<(1-methyl-3-pyridiniumcarbonyl)oxy>androst-4-en-3-one iodide (89648-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Heating

2: 71 percent / pyridine / 4 h / 100 °C

3: 92 percent / acetone / Heating

With thionyl chloride; In pyridine; acetone;

DOI:10.1002/jps.2600730324

Reference yield:

17β-<(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)oxy>androst-4-en-3-one (89648-34-0) → 17β-<(1-methyl-3-pyridiniumcarbonyl)oxy>androst-4-en-3-one iodide (89648-35-1)

Guidance literature:

With citrate phosphate dextrose; plasma; In water; dimethyl sulfoxide; at 37 ℃; Rate constant; Product distribution; also in 20percent brain homogenate and whole blood; also chemical oxidants (AgNO₃, H₂O₂, diphenylpicrylhydrazyl free radical), other solvents;

DOI:10.1002/jps.2600730324

upstream raw materials:

17β-<(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)oxy>androst-4-en-3-one

androst-4-en-3-on-17β-yl nicotinate

methyl iodide

nicotinic acid

Refernces

• 1、 -. "Testicular-specific drug delivery". . . Retrieved 2008/06/13.
• 2、 Bodor,Farag. "Improved delivery through biological membranes XIV: Brain-specific, sustained delivery of testosterone using a redox chemical delivery system". . p. 385 - 389. Retrieved 2007/10/02.