2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate

Base Information

• Chemical Name: 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate
• CAS No.: 1345985-94-5
• Molecular Formula: C₃₀H₃₁NO₅S
• Molecular Weight: 517.646
• Mol file: 1345985-94-5.mol

Synonyms:2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate

Chemical Property of 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate

There total 8 articles about 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-Naphthalenesulfonyl chloride (85-46-1) + rac-2-(N-tert-Butoxycarbonyl-N-benzylamino)-1-phenylethanol (215391-96-1) → 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate (1345985-94-5)

Guidance literature:

rac-2-(N-tert-Butoxycarbonyl-N-benzylamino)-1-phenylethanol; With potassium hydroxide; In tetrahydrofuran; for 0.25h;

1-Naphthalenesulfonyl chloride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.08.078

Reference yield:

styrene oxide (96-09-3) → 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate (1345985-94-5)

Guidance literature:

Multi-step reaction with 3 steps

1: activated silica / 24 h / Inert atmosphere

2: triethylamine / methanol / 0.5 h / Reflux

3: potassium hydroxide / tetrahydrofuran / 0.25 h

With triethylamine; potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2011.08.078

Reference yield:

2-benzylamino-1-phenyl-ethanol (51096-49-2,91579-12-3,107171-75-5,27159-30-4) → 2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate (1345985-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 0.5 h / Reflux

2: potassium hydroxide / tetrahydrofuran / 0.25 h

With triethylamine; potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2011.08.078

upstream raw materials:

styrene oxide

1-Naphthalenesulfonyl chloride

rac-2-(N-tert-Butoxycarbonyl-N-benzylamino)-1-phenylethanol

2-benzylamino-1-phenyl-ethanol

Refernces