1-cyclohexene-1-carbonyl azide

Base Information

• Chemical Name: 1-cyclohexene-1-carbonyl azide
• CAS No.: 101033-15-2
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 151.168
• Mol file: 101033-15-2.mol

Synonyms:1-cyclohexene-1-carbonyl azide

Chemical Property of 1-cyclohexene-1-carbonyl azide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclohexene-1-carbonyl azide

There total 5 articles about 1-cyclohexene-1-carbonyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

1-iodo-1-cyclohexene (17497-53-9) + carbon monoxide (201230-82-2) → 1-cyclohexene-1-carbonyl azide (101033-15-2)

Guidance literature:

With sodium azide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; hexane; water; at 50 ℃; under 750.075 Torr; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2021.132495

Reference yield:

cyclohexene-1-carboxylic acid (636-82-8) → 1-cyclohexene-1-carbonyl azide (101033-15-2)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In benzene; for 3h; Ambient temperature;

DOI:10.1021/jo00262a047

Reference yield:

1-cyclohexenoyl chloride (36278-22-5) → 1-cyclohexene-1-carbonyl azide (101033-15-2)

Guidance literature:

With sodium azide; In water; at 0 ℃; for 1h;

DOI:10.1021/jo00358a046

upstream raw materials:

cyclohexene-1-carboxylic acid

1-cyclohexenoyl chloride

1-iodo-1-cyclohexene

carbon monoxide

Downstream raw materials:

1-isocyanatocyclohex-1-ene

2-Pyrrolidin-1-yl-cyclohex-1-enecarboxylic acid cyclohex-1-enylamide

3-(cyclohexylamino)-1-<2-(2-bromo-4,5-dimethoxyphenyl)ethyl>-5,6-dihydro-2-oxo-4H-indole

1-Cyclohexylamino-4,5,6,7,9,10-hexahydro-8H-azepino[3,2,1-hi]indol-2-one

Refernces

• 1、 Mikle, Gábor,Skoda-F?ldes, Rita,Kollár, László. "Amino- and azidocarbonylation of iodoalkenes". supporting information. . Retrieved 2021/10/14.
• 2、 Matsubara, Ryosuke,Vital, Paulo,Nakamura, Yoshitaka,Kiyohara, Hiroshi,Kobayashi, Shu. "Highly diastereo- and enantioselective reactions of enecarbamates with an aldehyde". . p. 9769 - 9784. Retrieved 2007/10/03.