Technology Process of (-)-(2R)-2-methyl-4-hexenal
There total 21 articles about (-)-(2R)-2-methyl-4-hexenal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lead(IV) acetate; sodium carbonate;
In
dichloromethane;
at 0 ℃;
for 0.5h;
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - -20 ℃;
for 3h;
DOI:10.1016/S0040-4039(00)87837-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) triethylamine, trimethylacetyl chloride; 2.) n-butyllithium / 1.) THF, 10 min, -78 deg C and 30 min, 0 deg C; 2.) hexane, THF, 30 min, 0 deg C
2: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 4 h
3: 80 percent / lithium aluminum hydride / diethyl ether / 0.25 h / 0 °C
4: 1.) oxalyl chloride; 2.) triethylamine / 1.) dimethyl sulfoxide, methylene chloride, -78 deg C, 30 min; 2.) dimethyl sulfoxide, methylene chloride, -30 deg C, 1 h
With
lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine;
In
diethyl ether;
DOI:10.1021/ja00281a049
