4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID

Base Information

• Chemical Name: 4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID
• CAS No.: 4722-94-5
• Molecular Formula: C7H4ClNO4
• Molecular Weight: 201.56
• Hs Code.: 29333990
• Mol file: 4722-94-5.mol

Synonyms:4-Chloro-2,6-dipicolinicacid;4-Chlorodipicolinic acid;4-Chloropyridine-2,6-dicarboxylate;4-Chloropyridine-2,6-dicarboxylic acid;NSC 194835;

Chemical Property of 4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.79E-09mmHg at 25°C
• Melting Point: 210 °C
• Refractive Index: 1.639
• Boiling Point: 457.1 °C at 760 mmHg
• PKA: 2.60±0.10(Predicted)
• Flash Point: 230.2 °C
• PSA: 87.49000
• Density: 1.684 g/cm³
• LogP: 1.13140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-2,6-pyridinedicarboxylic Acid >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID

There total 15 articles about 4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dimethyl 4-chloro-2,6-pyridinedicarboxylate (5371-70-0) → 4-chloro-2,6-pyridinedicarboxylic acid (4722-94-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 1h;

DOI:10.1039/c2ob25830g

Reference yield: 84.0%

Chelidamic acid (499-51-4) → 4-chloro-2,6-pyridinedicarboxylic acid (4722-94-5)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; at 120 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/anie.201403403

Reference yield: 75.0%

chelidamic acid (138-60-3) → 4-chloro-2,6-pyridinedicarboxylic acid (4722-94-5)

Guidance literature:

chelidamic acid; With P,P-dichlorophenylphosphine oxide; at 120 ℃; for 2h; Inert atmosphere;

With water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.biochi.2011.05.022

upstream raw materials:

4-chloro-2,6-lutidine

4-chloropyridine-2,6-dicarbonyl dichloride

P,P-dichlorophenylphosphine oxide

Chelidamic acid

Downstream raw materials:

4-iodo-pyridine-2,6-dicarboxylic acid

Chelidamic acid

dimethyl 4-chloro-2,6-pyridinedicarboxylate

4-(dimethylamino)pyridine-2,6-dicarboxylic acid

Refernces

• 1、 Pitteri, Bruno,Cattalini, Lucio,Chessa, Gavino,Marangoni, Giampaolo,Stevanato, Nicoletta,Tobe, Martin L.. "Nucleophilic Substitution Reactions at Planar Four-co-ordinate Monoanionic Platinum(II) Complexes". . p. 3049 - 3054. Retrieved 1991.
• 2、 Kurosaki, Hiromasa,Sharma, Rakesh Kumar,Aoki, Sachiko,Inoue, Teruhiko,Okamoto, Yoshinari,Sugiura, Yukio,Doi, Mitsunobu,Ishida, Toshimasa,Otsuka, Masami,Goto, Masafumi. "Synthesis, characterization, and spectroscopic properties of three novel pentadentate copper(II) complexes related to the metalchelating inhibitors against DNA binding with HIV-EP1". . p. 441 - 447. Retrieved 2001.
• 3、 Chen, Allie Y.,Thomas, Pei W.,Stewart, Alesha C.,Bergstrom, Alexander,Cheng, Zishuo,Miller, Callie,Bethel, Christopher R.,Marshall, Steven H.,Credille, Cy V.,Riley, Christopher L.,Page, Richard C.,Bonomo, Robert A.,Crowder, Michael W.,Tierney, David L.,Fast, Walter,Cohen, Seth M.. "Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1". . p. 7267 - 7283. Retrieved 2017/09/22.