Technology Process of 2-iodo-α-methyl-benzenemethanol
There total 8 articles about 2-iodo-α-methyl-benzenemethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
diethyl ether;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol301154f
- Guidance literature:
-
1-(2-bromophenyl)ethanol;
With
diisopropylmagnesium; lithium 2-(dimethylamino)ethanolate;
In
diethyl ether;
at -40 - 20 ℃;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran;
at -20 - 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.200802488
- Guidance literature:
-
Multi-step reaction with 3 steps
1: thionyl chloride / diethyl ether / 2 h / Reflux
2: iron(III)-acetylacetonate / diethyl ether / -78 °C / Inert atmosphere
3: Candida tenuis AKR2B5 xylose reductase [E.(1)C11175]; water; NADH / ethanol / 25 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
With
thionyl chloride; iron(III)-acetylacetonate; Candida tenuis AKR2B5 xylose reductase [E.(1)C11175]; water; NADH;
In
diethyl ether; ethanol;
DOI:10.1039/c1ob05510k
