Technology Process of (1RS,2RS,3SR)-1-(3,5-dihydroxy-4-methoxyphenyl)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethylbutyl acetate
There total 21 articles about (1RS,2RS,3SR)-1-(3,5-dihydroxy-4-methoxyphenyl)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethylbutyl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 70 percent / triethlamine / 48 h / Heating
2: 33 percent / sulfuric acid / 20 h / Heating
3: 89 percent / hydrogen / 10percent palladium on charcoal / ethyl acetate
4: 88 percent / potassium cabonate / tetrahydrofuran / 36 h
5: 1.5 percent / lithium aluminium hydride / diethyl ether / 3 h / Heating
6: 76 percent / pyridine / 0 °C
7: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -78 deg C to RT, 4 h
8: 56 percent / sodium hydride / dimethylformamide / 12 h
9: LiAlH4 / diethyl ether / 15 h / 0 °C
10: pyridine
11: 87 percent / hydrogen / 10percent Pd/C / ethanol
With
pyridine; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium hydride; potassium carbonate; triethylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 33 percent / sulfuric acid / 20 h / Heating
2: 89 percent / hydrogen / 10percent palladium on charcoal / ethyl acetate
3: 88 percent / potassium cabonate / tetrahydrofuran / 36 h
4: 1.5 percent / lithium aluminium hydride / diethyl ether / 3 h / Heating
5: 76 percent / pyridine / 0 °C
6: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -78 deg C to RT, 4 h
7: 56 percent / sodium hydride / dimethylformamide / 12 h
8: LiAlH4 / diethyl ether / 15 h / 0 °C
9: pyridine
10: 87 percent / hydrogen / 10percent Pd/C / ethanol
With
pyridine; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium hydride; potassium carbonate; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
