p-Hydroxybenzoic acid ethyl ester sodium salt

Base Information

• Chemical Name: p-Hydroxybenzoic acid ethyl ester sodium salt
• CAS No.: 35285-68-8
• Molecular Formula: C9H9NaO3
• Molecular Weight: 188.158
• Hs Code.: 2918 29 00
• Mol file: 35285-68-8.mol

Synonyms:Benzoicacid, 4-hydroxy-, ethyl ester, sodium salt (9CI);4-Hydroxybenzoic acid ethyl ester sodiumsalt;E 215;Ethyl 4-hydroxybenzoate sodium salt;Ethyl p-hydroxybenzoatesodium salt;Sodium p-(carbethoxy)phenoxide;

Chemical Property of p-Hydroxybenzoic acid ethyl ester sodium salt

Chemical Property:

• Melting Point: >115°C(free ester)
• Boiling Point: 297.5 °C at 760 mmHg
• PKA: 8.4[at 20 ℃]
• Flash Point: 120.3 °C
• PSA: 49.36000
• Density: 1.34[at 20℃]
• LogP: 2.00710
• Storage Temp.: Store at +15°C to +25°C.
• Solubility.: White or almost white, hygroscopic, crystalline powder.
• Water Solubility.: 1000g/L at 23℃

Purity/Quality:

99% ^*data from raw suppliers

E215 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like methyl 4-hydroxybenzoate or propyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard ethyl 4-hydroxybenzoate.

Technology Process of p-Hydroxybenzoic acid ethyl ester sodium salt

There total 2 articles about p-Hydroxybenzoic acid ethyl ester sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenyl 4-ethoxycarbonyl phenyl (1268380-09-1) → sodium salicylat (81256-74-8) + sodium salt of ethyl-4-hydroxybenzoate (35285-68-8)

Guidance literature:

With water; sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; Kinetics;

DOI:10.5012/bkcs.2010.31.7.2015

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → sodium salt of ethyl-4-hydroxybenzoate (35285-68-8)

Guidance literature:

With sodium hydroxide; In water;

Reference yield: 74.0%

sodium salt of ethyl-4-hydroxybenzoate (35285-68-8) → hexakis[4-(ethoxycarbonyl)phenoxy]cyclotriphosphazene (84942-83-6)

Guidance literature:

With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; In 1,4-dioxane; at 110 ℃; for 72h; Inert atmosphere;

DOI:10.1021/ma200411g

upstream raw materials:

Ethyl 4-hydroxybenzoate

phenyl 4-ethoxycarbonyl phenyl

Downstream raw materials:

4-(ethoxycarbonyl)phenoxyacetic acid

O,O-Dimethyl-O-p-aethoxycarbonylphenyl-thiophosphat

O,O-Dimethyl-O-p-aethoxycarbonylphenyl-phosphat

hexakis[4-(ethoxycarbonyl)phenoxy]cyclotriphosphazene

Refernces

• 1、 -. "Process for the preparation of alkali metal salts of hydroxybenzoates, which are substantially anhydrous and free from hydroxybenzoic acid". . . Retrieved 2008/06/13.