Technology Process of 2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide
There total 7 articles about 2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
{4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid;
With
N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
2-amino-2-[3-(trifluoromethyl)phenyl]propanamide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 96 h / Reflux
1.2: pH 10
2.1: caesium carbonate / acetonitrile; water / 2 h / Reflux
3.1: lithium hydroxide / methanol / 0.5 h / 20 °C
4.1: benzotriazol-1-ol; N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C
4.2: 12 h / 20 °C
With
N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; caesium carbonate; sodium hydroxide; lithium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonia; ammonium chloride / ethanol; water / 20 h / 70 °C / Autoclave
2.1: hydrogenchloride; water / 20 °C / Cooling with ice
3.1: benzotriazol-1-ol; N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C
3.2: 12 h / 20 °C
With
hydrogenchloride; N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride; ammonia; water; ammonium chloride; benzotriazol-1-ol;
In
ethanol; water; N,N-dimethyl-formamide;