4'-(p-Fluorophenyl)acetanilide

Base Information

• Chemical Name: 4'-(p-Fluorophenyl)acetanilide
• CAS No.: 398-32-3
• Molecular Formula: C14H12 F N O
• Molecular Weight: 229.254
• Hs Code.: 2924299090
• European Community (EC) Number: 206-912-7
• NSC Number: 73090
• UNII: S59S53MB7A
• DSSTox Substance ID: DTXSID2020632
• Nikkaji Number: J33.445F
• Wikidata: Q63088211
• Mol file: 398-32-3.mol

Synonyms:4'-fluoro-4-biphenylacetamide

Chemical Property of 4'-(p-Fluorophenyl)acetanilide

Chemical Property:

• Melting Point: 205-207 °C
• Boiling Point: 416.1°Cat760mmHg
• Flash Point: 205.5°C
• PSA: 29.10000
• Density: 1.193g/cm³
• LogP: 3.52410
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 229.090292168
• Heavy Atom Count: 17
• Complexity: 253

Purity/Quality:

98%min ^*data from raw suppliers

4'-(4-FLUOROPHENYL)ACETANILIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)C2=CC=C(C=C2)F

Technology Process of 4'-(p-Fluorophenyl)acetanilide

There total 5 articles about 4'-(p-Fluorophenyl)acetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4-(acetylamino)benzenediazonium tetrafluoroborate + potassim 4-fluorophenyltrifluoroborate → N-(4'-fluorobiphenyl-4-yl)acetamide (398-32-3)

Guidance literature:

With palladium diacetate; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201500795

Reference yield:

4-fluoro-4'-nitro-1,1'-biphenyl (398-24-3) + acetic acid (64-19-7,77671-22-8) → N-(4'-fluorobiphenyl-4-yl)acetamide (398-32-3)

Guidance literature:

With iron; Heating;

DOI:10.1021/ja00966a026

Reference yield:

4'-(4-fluorophenyl)acetophenone oxime (725-15-5) → N-(4'-fluorobiphenyl-4-yl)acetamide (398-32-3)

Guidance literature:

With phosphorus pentachloride; In diethyl ether;

DOI:10.1039/jr9630002784

upstream raw materials:

4'-(4-fluorophenyl)acetophenone oxime

4-fluoro-4'-nitro-1,1'-biphenyl

acetic acid

Downstream raw materials:

4-amino-4'-fluorobiphenyl

Refernces