Serotonin hydrochloride

Base Information

• Chemical Name: Serotonin hydrochloride
• CAS No.: 153-98-0
• Molecular Formula: C10H12N2O^.HCl
• Molecular Weight: 212.679
• Hs Code.: 29339900
• European Community (EC) Number: 244-464-4,628-480-2
• UNII: GKN429M9VS
• DSSTox Substance ID: DTXSID80165186
• Wikidata: Q27279146
• Pharos Ligand ID: MNAP8MWU6R2P
• ChEMBL ID: CHEMBL535832
• Mol file: 153-98-0.mol

Synonyms:Serotonin hydrochloride;153-98-0;5-Hydroxytryptamine hydrochloride;Serotonin HCl;3-(2-aminoethyl)-1H-indol-5-ol hydrochloride;1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride;5-Hydroxytryptamine HCl;3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride;5-HT hydrochloride;CCRIS 4420;MFCD00012686;UNII-GKN429M9VS;GKN429M9VS;Serotonin hydrochloride(5-HT);CHEMBL535832;2-(5-hydroxy-1H-indol-3-yl)ethylazanium;chloride;SMR000875214;Prestwick_447;SR-01000075577;5-Hydroxytryptamine hydrochioride;Serotonin, HCl;3-(2-Aminoethyl)-5-hydroxyindole hydrochloride;3-(2-aminoethyl)indol-5-ol, chloride;5-Hydroxytrptamine HCl;5-HT HCl;C10H12N2O.ClH;MLS001332607;MLS001332608;MLS002153834;SCHEMBL379650;Serotonin hydrochloride, powder;3-(2-AMINO-ETHYL)-1H-INDOL-5-OL HYDROCHLORIDE;DTXSID80165186;5-hydroxy tryptamine hydrochloride;CHEBI:181195;HMS1569B03;3-(2-Aminoethyl)indol-5-ol HCl;BCP20357;HY-B1473;EINECS 244-464-4;SEROTONIN HYDROCHLORIDE [MI];Tox21_500607;s4244;5-Hydroxytryptamine Hydrochloride,(S);AKOS016010442;CCG-214216;CS-T-42259;GS-3130;LP00607;3-(2-Aminoethyl)-1H-indol-5-ol HCl;NCGC00093982-01;NCGC00093982-02;NCGC00261292-01;LS-83659;SY061788;3-(2-Aminoethyl)indol-5-ol hydrochloride;CS-0013171;EU-0100607;FT-0631852;S0370;SW196666-3;A16699;H 9523;H-8140;3-(2-aminoethyl)-1H-indol-5-ol, hydrochloride;hydrochloride.;EN300-1590677;A809482;SR-01000075577-1;SR-01000075577-5;Q27279146;3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride (1:1);Z1741979085;21591-86-6

Chemical Property of Serotonin hydrochloride

Chemical Property:

• Appearance/Colour: white to cream powder
• Vapor Pressure: 1.63E-07mmHg at 25°C
• Melting Point: 168-172 °C
• Boiling Point: 416.1 °C at 760 mmHg
• Flash Point: 205.4 °C
• PSA: 62.04000
• LogP: 2.87700
• Storage Temp.: 2-8°C
• Sensitive.: Light Sensitive & Hygroscopic
• Solubility.: H2O: 17 mg/mL
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.0716407
• Heavy Atom Count: 14
• Complexity: 174

Purity/Quality:

Analysis control,HPLC≥98% ^*data from raw suppliers

Serotonin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi,Hazard
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Other Biomolecules
• Canonical SMILES: C1=CC2=C(C=C1O)C(=CN2)CCN.Cl
• Uses: Serotonin hydrochloride is used as a neurotransmitter and function as an endogenous serotonin receptor agonist in various biochemical processes. It is an active component, which is used to regulate the mood, emesis, cognition and appetite in vivo. A neurotransmitter. Neurotransmitter;5-HT agonist Serotonin is a monoamine neurotransmitter. Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract. Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low levels of serotonin are associated with several disorders, including depression, migraines, bipolar disorder, and anxiety. Its actions are terminated primarily via uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with MDMA, cocaine, tricyclic antidepressants, and selective serotonin reuptake inhibitors.[Cayman Chemical]

Technology Process of Serotonin hydrochloride

There total 2 articles about Serotonin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C10H10N2O3 → serotonin hydrochloride (153-98-0,21591-86-6)

Guidance literature:

C₁₀H₁₀N₂O₃; With hydrogen; In methanol; at 30 ℃; Autoclave; Industrial scale;

With hydrogenchloride; In methanol; water; Autoclave; Industrial scale;

Reference yield:

tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate (53157-48-5) → serotonin hydrochloride (153-98-0,21591-86-6)

Guidance literature:

With hydrogenchloride; In methanol; water; ethyl acetate; at 25 ℃; for 0.166667h;

Reference yield: 98.8%

serotonin hydrochloride (153-98-0,21591-86-6) + acetyl chloride (75-36-5) → N-acetyl-5-hydroxytryptamine (1210-83-9)

Guidance literature:

With sodium hydrogencarbonate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3.5h; Reagent/catalyst; Temperature;

upstream raw materials:

tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate

Downstream raw materials:

(2S,4R)-2-<(5-hydroxy-1H-indol-3-yl)methyl>thiazolidine

(2R,4R)-2-<(5-hydroxy-1H-indol-3-yl)methyl>thiazolidine

tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate

Hydroxyindoleacetaldehyde

Refernces

• 1、 -. "Method for preparing 5-hydroxytryptamine hydrochloride by utilizing enzymatic fermentation liquor containing 5-hydroxytryptamine". Paragraph 0032; 0035-0037; 0038; 0041-0043; 0044; 0047-0049. . Retrieved 2021/02/13.