Technology Process of {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol
There total 4 articles about {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; potassium iodide;
In
N,N-dimethyl-formamide;
at 50 - 68 ℃;
DOI:10.1080/00397919608004796
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99 percent / triethylamine / tetrahydrofuran; H2O / 2 h / 25 °C
2: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C
3: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr
4: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C
With
hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine; potassium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
1: Carboxylation / 2: Phenylation / 3: Hydrogenolysis / 4: Alkylation;
DOI:10.1080/00397919608004796
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr
2: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C
With
hydrogen; sodium hydrogencarbonate; acetic acid; potassium iodide;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide;
1: Hydrogenolysis / 2: Alkylation;
DOI:10.1080/00397919608004796