3-Phenyl-1-indanone

Base Information

• Chemical Name: 3-Phenyl-1-indanone
• CAS No.: 16618-72-7
• Molecular Formula: C15H12O
• Molecular Weight: 208.26
• Hs Code.: 2914399090
• European Community (EC) Number: 625-438-5
• NSC Number: 82364
• DSSTox Substance ID: DTXSID701314027
• Nikkaji Number: J36.988H
• ChEMBL ID: CHEMBL1571712
• Mol file: 16618-72-7.mol

Synonyms:3-Phenyl-1-indanone;16618-72-7;3-Phenyl-2,3-dihydro-1H-inden-1-one;1-Indanone, 3-phenyl-;1H-Inden-1-one, 2,3-dihydro-3-phenyl-;3-Phenylindan-1-one;3-Phenylindanone;3-phenyl-2,3-dihydroinden-1-one;NSC 82364;BRN 1370263;4-07-00-01673 (Beilstein Handbook Reference);NSC82364;MLS000691949;SCHEMBL181713;3-Phenyl-1-indanone, 98%;WLN: L56 BVT&J DR;(+/-)-3-Phenyl-1-indanone;CHEMBL1571712;DTXSID701314027;HMS2629C20;AMY13690;3-phenyl-2,3-dihydro-inden-1-one;MFCD00037722;NSC-82364;AKOS004119419;AKOS016038080;1H-Inden-1-one,3-dihydro-3-phenyl-;NCGC00246563-01;LS-81336;SMR000333984;1H-Indene-1-one, 2,3-dihydro-3-phenyl-;CS-0315124;FT-0616326;9K-043;I10111;A810702;J-010263

Chemical Property of 3-Phenyl-1-indanone

Chemical Property:

• Vapor Pressure: 0.00016mmHg at 25°C
• Melting Point: 75-78 °C
• Refractive Index: 1.62
• Boiling Point: 331 °C at 760 mmHg
• Flash Point: 142.3 °C
• PSA: 17.07000
• Density: 1.162 g/cm³
• LogP: 3.40490
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 208.088815002
• Heavy Atom Count: 16
• Complexity: 265

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Phenyl-1-indanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(C2=CC=CC=C2C1=O)C3=CC=CC=C3

Technology Process of 3-Phenyl-1-indanone

There total 112 articles about 3-Phenyl-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(α-styryl)benzaldehyde (871563-46-1) → 3-phenyl-1-indanone (16618-72-7)

Guidance literature:

With hydrogen; [Rh(nbd)(dppe)]ClO₄; In diethyl ether; 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.08.061

Reference yield: 98.0%

3,3-Diphenylpropionic acid (606-83-7) → 3-phenyl-1-indanone (16618-72-7)

Guidance literature:

3,3-Diphenylpropionic acid; With pyridine; 1,3,5-trichloro-2,4,6-triazine; In dichloromethane; at 20 ℃; for 0.25h;

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.416667h;

DOI:10.1021/ol800752v

Reference yield: 94.0%

β-Phenylacrylic acid 4-nitroanilide (134430-90-3,74948-33-7) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3-phenyl-1-indanone (16618-72-7)

Guidance literature:

With trifluorormethanesulfonic acid; at 50 ℃;

upstream raw materials:

(E)-3-phenylacrylic acid

3,3-Diphenylpropionic acid

3,3-diphenylpropanoyl chloride

3-phenyl-1H-inden-1-one

Downstream raw materials:

2-bromo-3-phenyl-1H-inden-1-one

3-phenyl-1H-inden-1-one

2-bromo-3-phenyl-1-indanone

2-hydroxymethylene-3-phenylindan-1-one

Refernces

• 1、 Talavera,Bolano,Bravo,Castro,Garcia-Fontan,Hermida-Ramon. "Formation of indanone from an iridanaphthalene complex". . p. 4058 - 4060. Retrieved 2013.
• 2、 Liu, Yueqiang,Chen, Lingjuan,Liu, Yan,Liu, Ping,Dai, Bin. "Synthesis of 3-aryl-1-indanones via CsF-promoted coupling of arylboronic acids with N-tosylhydrazones". . p. 40 - 43. Retrieved 2018.
• 3、 Kende,Bogard. "". . p. 3383. Retrieved 1967.
• 4、 Pawar, Samir Kundlik,Wang, Chiou-Dong,Bhunia, Sabyasachi,Jadhav, Appaso Mahadev,Liu, Rai-Shung. "Gold-catalyzed formal cycloaddition of 2-ethynylbenzyl ethers with organic oxides and α-diazoesters". . p. 7559 - 7563. Retrieved 2013.
• 5、 Koltunov, Konstantin Yu.,Walspurger, Stéphane,Sommer, Jean. "Cyclization of 1-phenyl-2-propen-1-ones into 1-indanones using H-zeolite and other solid acids. The role of mono- and dicationic intermediates". . p. 8391 - 9394. Retrieved 2005.
• 6、 Chen, Yate,Ding, Zhengtian,Wang, Yiming,Liu, Wenfeng,Kong, Wangqing. "Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy". supporting information. p. 5273 - 5278. Retrieved 2021/02/03.
• 7、 Parveen, Naziya,Sekar, Govindasamy. "Palladium Nanoparticles-Catalyzed Synthesis of Indanone Derivatives via Intramolecular Reductive Heck Reaction". . p. 4581 - 4595. Retrieved 2019/09/03.