(3-Chloroanilino)azanium;chloride

Base Information

• Chemical Name: (3-Chloroanilino)azanium;chloride
• CAS No.: 2312-23-4
• Molecular Formula: C6H7ClN2^.HCl
• Molecular Weight: 179.049
• Hs Code.: 29280000
• Mol file: 2312-23-4.mol

Synonyms:(3-chloroanilino)azanium;chloride

Chemical Property of (3-Chloroanilino)azanium;chloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00887mmHg at 25°C
• Melting Point: 240-245 °C (dec.)(lit.)
• Boiling Point: 266 °C at 760 mmHg
• Flash Point: 114.7 °C
• PSA: 38.05000
• LogP: 3.20090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 178.0064537
• Heavy Atom Count: 10
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

3-Chlorophenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-43-20/21/22
• Safety Statements: 36/37-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)N[NH3+].[Cl-]
• Uses: 3-Chlorophenylhydrazine hydrochloride has been used in the preparation of:1-(3-chlorophenyl)-3,5-diphenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one11-(3-chlorophenyl)-9-phenyl-5,6-dihydro-4H,11H-benzo[i,j]- pyrazolo[3,4-b]quinolizin-8-one1-(3-chlorophenyl)-3-(cyclohexyl)-5-(4-phenoxy phenyl)pyrazole

Technology Process of (3-Chloroanilino)azanium;chloride

There total 4 articles about (3-Chloroanilino)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-bromo-3-chlorobenzene (108-37-2) → m-chlorophenylhydrazine hydrochloride (2312-23-4)

Guidance literature:

1-bromo-3-chlorobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 80.0%

→ m-chlorophenylhydrazine hydrochloride (2312-23-4)

Guidance literature:

Reference yield:

3-chloro-aniline (108-42-9) → m-chlorophenylhydrazine hydrochloride (2312-23-4)

Guidance literature:

With diazotizing agent; tin(ll) chloride; Multistep reaction;

DOI:10.1002/ardp.19943270208

upstream raw materials:

3-chloro-aniline

3-Nitrochlorobenzene

1-bromo-3-chlorobenzene

Downstream raw materials:

2-<2-(3-chlorophenyl)hydrazino>tropone

3-(3-chloro-phenylamino)-2-mercapto-5-methyl-3H-imidazole-4-carboxylic acid methyl ester

1-(3-chloro-phenylamino)-4-ethyl-5-phenyl-1H-imidazole-2-thiol

[(3-chloro-phenyl)-hydrazono]-(3-hydroxy-benzofuran-2-yl)-acetic acid ethyl ester

Refernces

• 1、 Bi, Fangchao,Song, Di,Qin, Yinhui,Liu, Xingbang,Teng, Yuetai,Zhang, Na,Zhang, Panpan,Zhang, Nan,Ma, Shutao. "Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains". . p. 3179 - 3193. Retrieved 2019/06/17.
• 2、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.