METHACYCLINE

Base Information

• Chemical Name: METHACYCLINE
• CAS No.: 914-00-1
• Molecular Formula: C₂₂H₂₂N₂O₈
• Molecular Weight: 442.425
• Mol file: 914-00-1.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-(8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,[4S-(4a,4aa,5a,5aa,12aa)]-;4-Dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide;6-Demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline;6-Deoxy-6-methylene-6-demethyl-5-hydroxytetracycline; 6-Methylene-5-hydroxytetracycline;6-Methyleneoxytetracycline; Bialatan; GS 2876; Metacycline; Methacycline;Oxytetracycline, 6-methylene-; Rondomycin; Tri-methacycline

Chemical Property of METHACYCLINE

Chemical Property:

• Vapor Pressure: 2.8E-20mmHg at 25°C
• Melting Point: 205 °C (decomp)
• Refractive Index: 1.6500 (estimate)
• Boiling Point: 695.1°Cat760mmHg
• PKA: pKa 3.5 (Uncertain);7.6 (Uncertain);9.5(EtOH/H2O t=20.0) (Uncertain)
• Flash Point: 374.2°C
• PSA: 181.62000
• Density: 1.66g/cm³
• LogP: 0.26240
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: 7.548g/L(21 oC)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methacycline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methacycline is used for the same indications as other antibiotics of the tetracycline series. In some cases it is tolerated better than tetracyclines. Synonyms of this drug are rondomycin, methamycin, adramycin, and others. Methacycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of oxytetracycline to yield an exocyclic 6-methylene. Like all tetracyclines, methacycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Methacycline has been extensively cited in the literature with over 400 references. Methacycline is a tetracycline with broad range antibacterial and antiprotozoal properties. Potential veterinary drug.
• Therapeutic Function: Antibiotic

Technology Process of METHACYCLINE

There total 3 articles about METHACYCLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ methacycline (914-00-1,138245-75-7)

Guidance literature:

Reference yield:

→ methacycline (914-00-1,138245-75-7)

Guidance literature:

11a-Chlor-6-desoxy-6-desmethyl-6-methylen-5-hydroxytetracyclin bzw.dem Hydrofluorid oder Toluol-4-sulfonat, N2H4, Pd/Kohle oder Pt/Kohle;

Reference yield:

→ 6-Methylen-5-hydroxy-tetracyclin (914-00-1,138245-75-7)

Guidance literature:

5-Hydroxy-tetracyclin-schwefelsaeureester (16), fl. HF, 1h, 0-5grad;

DOI:10.1021/ja00907a010

Refernces

• 1、 -. "Manufacture of 6-methylenetetracyclines". . . Retrieved 2008/06/13.