N-(2-Hydroxyethyl)dodecanamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)dodecanamide
• CAS No.: 142-78-9
• Deprecated CAS: 123175-08-6,15517-65-4,65256-27-1,8028-85-1,15517-65-4,8028-85-1
• Molecular Formula: C14H29NO2
• Molecular Weight: 243.39
• Hs Code.: DERIVATION
• European Community (EC) Number: 205-560-1
• UNII: 098P2IGT76
• DSSTox Substance ID: DTXSID5025493
• Nikkaji Number: J103.087F
• Wikidata: Q27158443
• RXCUI: 1855084
• Metabolomics Workbench ID: 4685
• ChEMBL ID: CHEMBL246914
• Mol file: 142-78-9.mol

Synonyms:N-lauroylethanolamine;N-LEA

Chemical Property of N-(2-Hydroxyethyl)dodecanamide

Chemical Property:

• Appearance/Colour: Cream-colored flakes
• Vapor Pressure: 0.009Pa at 25℃
• Melting Point: 88-89 °C
• Boiling Point: 410.7 °C at 760 mmHg
• PKA: 14.49±0.10(Predicted)
• Flash Point: 202.2 °C
• PSA: 49.33000
• Density: 0.925 g/cm³
• LogP: 3.40670
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: 11.4mg/L at 20℃
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 12
• Exact Mass: 243.219829168
• Heavy Atom Count: 17
• Complexity: 172

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Hydroxyethyl)dodecanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Chemical Classes: Nitrogen Compounds -> Ethanolamines
• Canonical SMILES: CCCCCCCCCCCC(=O)NCCO

Technology Process of N-(2-Hydroxyethyl)dodecanamide

There total 9 articles about N-(2-Hydroxyethyl)dodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

ethyl laurate (106-33-2) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)dodecanamide (142-78-9)

Guidance literature:

With Novozym 435; In 1,4-dioxane; for 0.0833333h; chemoselective reaction; Microwave irradiation; Enzymatic reaction;

DOI:10.3762/bjoc.5.10

Reference yield: 97.0%

lauric acid (143-07-7) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)dodecanamide (142-78-9)

Guidance literature:

With Novozym 435; In 1,4-dioxane; for 0.0833333h; chemoselective reaction; Microwave irradiation; Enzymatic reaction;

DOI:10.3762/bjoc.5.10

Reference yield: 91.0%

→ N-(2-hydroxyethyl)dodecanamide (142-78-9)

Guidance literature:

upstream raw materials:

lauric acid

ethanolamine

methyl n-dodecanoate

ethyl laurate

Downstream raw materials:

2-(lauramido)ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionate

2-(1-phenylcarbamoyl-undecylidene)-oxazolidine-3-carboxylic acid anilide

N-dodecanoylglycine

N-myristoylglycine

Refernces

• 1、 -. "LIPO-GLYCOPEPTIDE CLEAVABLE DERIVATIVES AND USES THEREOF". Paragraph 237. . Retrieved 2020/06/10.
• 2、 Dalu, Francesca,Scorciapino, Mariano A.,Cara, Claudio,Luridiana, Alberto,Musinu, Anna,Casu, Mariano,Secci, Francesco,Cannas, Carla. "A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides". supporting information. p. 375 - 381. Retrieved 2018/02/07.