2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene

Base Information

• Chemical Name: 2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene
• CAS No.: 94828-03-2
• Molecular Formula: C₅₂H₆₀O₄S
• Molecular Weight: 781.112
• Mol file: 94828-03-2.mol

Synonyms:2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene

Chemical Property of 2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene

There total 2 articles about 2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2E,6E)-3,7,11-trimethyl-1-(p-tolylsulfonyl)dodeca-2,6,10-triene (68690-45-9,80370-68-9,53254-63-0) + 1,4-Bis-benzyloxy-2-((E)-4-bromo-3-methyl-but-2-enyl)-3-methyl-naphthalene (94828-04-3) → 2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene (94828-03-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane; at -70 - 0 ℃;

Reference yield:

(E)-4-(1,4-Bis-benzyloxy-3-methyl-naphthalen-2-yl)-2-methyl-but-2-en-1-ol (94828-30-5) → 2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene (94828-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PBr₃ / diethyl ether / 1.5 h / 0 °C

2: 87 percent / 1.) hexamethylphosphoric triamide, BuLi / tetrahydrofuran; hexane / -70 - 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; phosphorus tribromide; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

2-(5'-p-tosyl-tetraprenyl)-3-methyl-1,4-dibenzyloxynaphthalene (94828-03-2) → menatetrenone (863-61-6) + 2-Methyl-3-((2E,5E,10E)-3,7,11,15-tetramethyl-hexadeca-2,5,10,14-tetraenyl)-[1,4]naphthoquinone

Guidance literature:

With oxygen; lithium; ethylamine; Yield given. Multistep reaction; 1.) THF, -70 deg C; 2.) THF, MeOH, H₂O, Et₂O;

upstream raw materials:

(2E,6E)-3,7,11-trimethyl-1-(p-tolylsulfonyl)dodeca-2,6,10-triene

1,4-Bis-benzyloxy-2-((E)-4-bromo-3-methyl-but-2-enyl)-3-methyl-naphthalene

(E)-4-(1,4-Bis-benzyloxy-3-methyl-naphthalen-2-yl)-2-methyl-but-2-en-1-ol

Downstream raw materials:

menatetrenone

menahydroquinone-4

Refernces