4,4'-(Furan-2,5-diyl)dibenzimidamide dihydrochloride

Base Information

• Chemical Name: 4,4'-(Furan-2,5-diyl)dibenzimidamide dihydrochloride
• CAS No.: 55368-40-6
• Molecular Formula: C18H16 N4 O . 2 Cl H
• Molecular Weight: 0
• DSSTox Substance ID: DTXSID90970703
• Mol file: 55368-40-6.mol

Synonyms:55368-40-6;Furamidine Dihydrochloride;4,4'-(Furan-2,5-diyl)dibenzimidamide dihydrochloride;Furamidine (dihydrochloride);Furamidine HCl;db75-dihydrochloride;SCHEMBL7734063;DTXSID90970703;4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride;AKOS025147335;SB60935;MS-26130;HY-110137;CS-0032994;4,4'-(Furan-2,5-diyl)dibenzimidamidedihydrochloride;DB 75, DB75, NSC 305831, WR199385;4,4'-(2,5-Furandiyl)dibenzenecarboximidamide dihydrochloride;4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide;dihydrochloride

Chemical Property of 4,4'-(Furan-2,5-diyl)dibenzimidamide dihydrochloride

Chemical Property:

• Melting Point: 400-401 °C(Solv: ethanol (64-17-5))
• PSA: 112.88000
• LogP: 5.58380
• Storage Temp.: -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 376.0857666
• Heavy Atom Count: 25
• Complexity: 396

Purity/Quality:

98%,99%, ^*data from raw suppliers

Furamidine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N.Cl.Cl
• Description: Furamidinedihydrochloride (DB75dihydrochloride) is a selective and cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 9.4 μM. Furamidinedihydrochloride is more selective for PRMlookchemT1 than PRMT5, PRMT6 and PRMT4(CARM1) (IC50 of 166μM, 283μM and >400μM, respectively). Furamidinedihydrochloride is a potent, reversible and competitive inhibitor of tyrosyl DNA phosphodiesterase 1 (TDP-1).
• Uses: Furamidine is a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines.