N-Glycyl-L-tyrosine

Base Information

• Chemical Name: N-Glycyl-L-tyrosine
• CAS No.: 658-79-7
• Molecular Formula: C11H14N2O4
• Molecular Weight: 238.243
• Hs Code.: 29242990
• NSC Number: 118362,206246,83260
• Nikkaji Number: J2.260.027C
• Mol file: 658-79-7.mol

Synonyms:L-Tyrosine,N-glycyl-;Tyrosine, N-glycyl-, L- (8CI);5: PN: WO2008106043 TABLE: 6 claimedprotein;Glycine-tyrosine;Glycyl-L-tyrosine;Glycyltyrosine;N-Glycyltyrosine;NSC 83260;

Chemical Property of N-Glycyl-L-tyrosine

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 9.28E-14mmHg at 25°C
• Melting Point: 278-285 °C (dec.)
• Refractive Index: 47.5 ° (C=1, H2O)
• Boiling Point: 568.4 °C at 760 mmHg
• PKA: 2.95±0.10(Predicted)
• Flash Point: 297.6 °C
• PSA: 112.65000
• Density: 1.362 g/cm³
• LogP: 0.55400
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
• Water Solubility.: 44.1g/L at 25℃
• XLogP3: -3.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 238.09535693
• Heavy Atom Count: 17
• Complexity: 275

Purity/Quality:

99% ^*data from raw suppliers

Glycyl-L-tyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)NC(=O)CN)O

Technology Process of N-Glycyl-L-tyrosine

There total 19 articles about N-Glycyl-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

H-AspPheGlyAsnLysThrPheGlyTyr-OH → N-Gly-Tyr (658-79-7) + Asp-Phe-OH (3918-98-7,13433-09-5,108147-48-4,108147-49-5,130818-77-8) + (S)-2-((2S,3R)-2-{(S)-6-Amino-2-[(S)-2-(2-amino-acetylamino)-3-carbamoyl-propionylamino]-hexanoylamino}-3-hydroxy-butyrylamino)-3-phenyl-propionic acid

Guidance literature:

With C_. subtilisin; at 37 ℃; for 7h; pH=7.8; Enzyme kinetics;

DOI:10.1016/S0968-0896(99)00021-8

Reference yield:

2-(2-chloroacetamido)-3-(4-hydroxyphenyl)propanoic acid (1145-56-8) + ammonium bicarbonate (1066-33-7,6721-33-1,10361-29-2) → N-Gly-Tyr (658-79-7)

Guidance literature:

With ammonium hydroxide; In water;

Reference yield:

Cbz-G-Y-OH (7801-35-6) → N-Gly-Tyr (658-79-7)

Guidance literature:

With methanol; palladium; Hydrogenation;

upstream raw materials:

Cbz-G-Y-OH

N-(N-benzyloxycarbonyl-glycyl)-L-tyrosine benzyl ester

O-benzyl-N-(N-benzyloxycarbonyl-glycyl)-L-tyrosine

L-tyrosine

Downstream raw materials:

H-Gly-Tyr-OMe

N-glycyl-L-tyrosine ethyl ester

N-glycyl-3,5-diiodo-tyrosine

Cbz-G-Y-OH

Refernces

• 1、 Klotz, Alan V.,Thomas, Beth Ann. "N5-Methylasparagine and Asparagine as Nucleophiles in Peptides: Main-Chain vs Side-Chain Amide Cleavage". . p. 6985 - 6989. Retrieved 1993.
• 2、 -. "Process for producing N-glycyltyrosine and its crystal structure". . . Retrieved 2008/06/13.