2,4-dimethylphenylhydroxylamine

Base Information

• Chemical Name: 2,4-dimethylphenylhydroxylamine
• CAS No.: 70853-94-0
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Mol file: 70853-94-0.mol

Synonyms:N-Hydroxy-2,4-dimethylaniline;NSC 337227

Chemical Property of 2,4-dimethylphenylhydroxylamine

Chemical Property:

• Vapor Pressure: 0.0214mmHg at 25°C
• Boiling Point: 239.8°C at 760 mmHg
• Flash Point: 108.5°C
• PSA: 32.26000
• Density: 1.12g/cm³
• LogP: 2.17750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dimethylphenylhydroxylamine

There total 4 articles about 2,4-dimethylphenylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethylnitrobenzene (89-87-2,156617-89-9,37551-97-6) → N-(2,4-dimethylphenyl)hydroxylamine (70853-94-0)

Guidance literature:

With ethanol; ammonium chloride; zinc;

Reference yield:

2,4-dimethylnitrobenzene (89-87-2,156617-89-9,37551-97-6) → N-(2,4-dimethylphenyl)hydroxylamine (70853-94-0) + 2,4-Xylidine (95-68-1)

Guidance literature:

With glucose dehydrogenase; sodium molybdate; D-glucose; nicotinamide adenine dinucleotide phosphate; Met-Asp-Ile-Ile-Ser-Val-Ala-Leu-Lys-Arg-His-Ser-Thr-Lys-Ala-Phe-Asp-Ala-Ser-Lys-Lys-Leu-Thr-Pro-Glu-Gln-Ala-Glu-Gln-Ile-Lys-Thr-Leu-Leu-Gln-Tyr-Ser-Pro-Ser-Ser-Thr-Asn-Ser-Gln-Pro-Trp-His-Phe-Ile-Val-Ala-Ser-Thr-Glu-Glu-Gly-Lys-Ala-Arg-Val-Ala-Lys-Ser-Ala-Ala-Gly-Asn-Tyr-Val-Phe-Asn-Glu-Arg-Lys-Met-Leu-Asp-Ala-Ser-His-Val-Val-Val-Phe-Cys-Ala-Lys-Thr-Ala-Met-Asp-Asp-Val-Trp-Leu-Lys-Leu-Val-Val-Asp-Gin-Glu-Asp-Ala-Asp-Gly-Arg-Phe-Ala-Thr-Pro-Glu-Ala-Lys-Ala-Ala-Asn-Asp-Lys-Gly-Arg-Lys-Phe-Phe-Ala-Asp-Met-His-Arg-Lys-Asp-Leu-His-Asp-Asp-Ala-Glu-Trp-Met-Ala-Lys-Gln-Val-Tyr-Leu-Asn-Val-dy-Asn-Phe-Leu-Leu-Gly-Val-Ala-Ala-Leu-Gly-Leu-Asp-Gly-Leu-Lys-Glu-Lys-Gly-Tyr-Thr-Ser-Leu-Val-Val-Val-Pro-Val-Gly-His-His-Ser-Val-Glu-Asp-Phe-Asn-Ala-Thr-Leu-Pro-Lys-Ser-Arg-Leu-Pro-Gln-Asn-Ile-Thr-Leu-Thr-Glu-Val; nicotinamide adenine dinucleotide; In aq. phosphate buffer; tert-butyl methyl ether; at 35 ℃; for 18h; Enzymatic reaction;

Reference yield:

2,4-dimethylnitrobenzene (89-87-2,156617-89-9,37551-97-6) → N-(2,4-dimethylphenyl)hydroxylamine (70853-94-0) + C16H18N2O

Guidance literature:

With glucose dehydrogenase; D-glucose; nicotinamide adenine dinucleotide phosphate; Met-Asp-Ile-Ile-Ser-Val-Ala-Leu-Lys-Arg-His-Ser-Thr-Lys-Ala-Phe-Asp-Ala-Ser-Lys-Lys-Leu-Thr-Pro-Glu-Gln-Ala-Glu-Gln-Ile-Lys-Thr-Leu-Leu-Gln-Tyr-Ser-Pro-Ser-Ser-Thr-Asn-Ser-Gln-Pro-Trp-His-Phe-Ile-Val-Ala-Ser-Thr-Glu-Glu-Gly-Lys-Ala-Arg-Val-Ala-Lys-Ser-Ala-Ala-Gly-Asn-Tyr-Val-Phe-Asn-Glu-Arg-Lys-Met-Leu-Asp-Ala-Ser-His-Val-Val-Val-Phe-Cys-Ala-Lys-Thr-Ala-Met-Asp-Asp-Val-Trp-Leu-Lys-Leu-Val-Val-Asp-Gin-Glu-Asp-Ala-Asp-Gly-Arg-Phe-Ala-Thr-Pro-Glu-Ala-Lys-Ala-Ala-Asn-Asp-Lys-Gly-Arg-Lys-Phe-Phe-Ala-Asp-Met-His-Arg-Lys-Asp-Leu-His-Asp-Asp-Ala-Glu-Trp-Met-Ala-Lys-Gln-Val-Tyr-Leu-Asn-Val-dy-Asn-Phe-Leu-Leu-Gly-Val-Ala-Ala-Leu-Gly-Leu-Asp-Gly-Leu-Lys-Glu-Lys-Gly-Tyr-Thr-Ser-Leu-Val-Val-Val-Pro-Val-Gly-His-His-Ser-Val-Glu-Asp-Phe-Asn-Ala-Thr-Leu-Pro-Lys-Ser-Arg-Leu-Pro-Gln-Asn-Ile-Thr-Leu-Thr-Glu-Val; nicotinamide adenine dinucleotide; iron(II) chloride; In aq. phosphate buffer; tert-butyl methyl ether; at 35 ℃; for 18h; Reagent/catalyst; Enzymatic reaction;

upstream raw materials:

2,4-dimethylnitrobenzene

Downstream raw materials:

2,2'-dihydroxy-3,3',5,5'-tetramethylbiphenyl

4-hydroxy-2,4-dimethyl-2,5-cyclohexadienone

5-chloro-2,4-dimethylaniline

2-chloro-4,6-dimethylaniline

Refernces

• 1、 Ishida, Yasuhiro,Nakamura, Itaru,Tashiro, Hiroki,Terada, Masahiro. "Synthesis of meta-substituted anilines via copper-catalyzed [1,3]-methoxy rearrangement". supporting information. p. 3794 - 3798. Retrieved 2020/06/08.