Chemical Property of Chlamydocin
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Chemical Property:
- Vapor Pressure:4.49E-30mmHg at 25°C
- Boiling Point:861.8°Cat760mmHg
- PKA:13.36±0.70(Predicted)
- Flash Point:475°C
- PSA：137.21000
- Density:1.27g/cm3
- LogP:1.94080
- XLogP3:1.7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:9
- Exact Mass:526.27913494
- Heavy Atom Count:38
- Complexity:915
- Purity/Quality:
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98%Min *data from raw suppliers
Chlamydocin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)CCCCCC(=O)C3CO3)CC4=CC=CC=C4)C
- Isomeric SMILES:CC1(C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)CCCCCC(=O)[C@@H]3CO3)CC4=CC=CC=C4)C
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Description
Chlamydocin is a histone deacetylase (HDAC) inhibitor that was originally isolated from D. chlamydosporia and has anticancer properties. It is selective for HDAC1 over HDAC6 (IC50 = 0.15 and 1,100 nM, respectively). Chlamydocin increases acetylation of histone H3 and histone H4 in A2780 cells when used at concentrations ranging from 1 to 1,000 nM. It inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively). Chlamydocin increases lifespan by 10% in a P185 mouse allograft model when administered at doses ranging from 20 to 160 mg/kg.
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Uses
Chlamydocin is a cyclic tetrapeptide and an irreversible histone deacetylase (HDAC) inhibitor.
