Technology Process of 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-hydroxyethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide
There total 8 articles about 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-hydroxyethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jm500535j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sulfuric acid / 12 h / Reflux
2: ethanol / 120 °C / Inert atmosphere; Microwave irradiation
3: hydrogen; palladium on activated charcoal / methanol / 3 h / 20 °C / Inert atmosphere
4: potassium carbonate / water; ethanol / 13 h / 80 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
6: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; sulfuric acid; palladium on activated charcoal; hydrogen; potassium carbonate;
In
methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500535j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ethanol / 120 °C / Inert atmosphere; Microwave irradiation
2: hydrogen; palladium on activated charcoal / methanol / 3 h / 20 °C / Inert atmosphere
3: potassium carbonate / water; ethanol / 13 h / 80 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
5: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; palladium on activated charcoal; hydrogen; potassium carbonate;
In
methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500535j