(2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydron;chloride

Base Information

• Chemical Name: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydron;chloride
• CAS No.: 2219-30-9
• Molecular Formula: C5H11 N O2 S . Cl H
• Molecular Weight: 185.675
• Hs Code.: 2930909090
• Mol file: 2219-30-9.mol

Synonyms:

Chemical Property of (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydron;chloride

Chemical Property:

• Vapor Pressure: 0.00631mmHg at 25°C
• Melting Point: 177.5 °C (decomp)
• Boiling Point: 251.8°Cat760mmHg
• Flash Point: 106.1°C
• PSA: 102.12000
• Density: 1.204g/cm³
• LogP: 1.60900
• Storage Temp.: 2-8°C
• Solubility.: Aqueous Base (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 185.0277275
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CC(C)(C(C(=O)O)N)S.[Cl-]
• Isomeric SMILES: [H+].CC(C)([C@H](C(=O)O)N)S.[Cl-]
• Uses: D-Penicillamine Hydrochloride showed protective effect on mitochondrial respiration in the brain. It is used in the treatment of Wilson’s disease and heavy metal poisoning. D-Penicillamine Hydrochloride is the salt form of D-Penicillamine (P223000).
• Therapeutic Function: Antiarthritic

Technology Process of (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydron;chloride

There total 6 articles about (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3,3-dimethyl-D-cysteine (52-67-5) + D-penicillamine hydrochloride (2219-30-9)

Guidance literature:

Reference yield:

acid α-benzylamide + 2-amino-benzenethiol (137-07-5) → D-penicillamine hydrochloride (2219-30-9)

Guidance literature:

With hydrogenchloride; In water;

Reference yield:

D-4-carboxy-2,2,5,5-tetramethylthiazolidine hydrochloride (17266-78-3,33078-43-2,55234-20-3) → D-penicillamine hydrochloride (2219-30-9)

Guidance literature:

With hydrogenchloride; In water; for 0.15h; Heating;

DOI:10.1139/v81-062

upstream raw materials:

D-4-carboxy-2,2,5,5-tetramethylthiazolidine hydrochloride

(2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid dihydrochloride

2-amino-benzenethiol

Downstream raw materials:

(S)-5,5-dimethyl-2-phenyl-4,5-dihydro-thiazole-4-carboxylic acid

D-penicillamine methyl ester hydrochloride

(5R)-6c-azido-3,3-dimethyl-7-oxo-5-phenyl-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

(5R)-3,3-dimethyl-4t,7-dioxo-6c-(2-phenoxy-acetylamino)-5-phenyl-(5rH)-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

Refernces

• 1、 Wolfe,Bowers,Hasan,Kazmaier. "Synthesis and conformations of α-aminoadipyl- and glycyl-α-aminoadipylthiazepine sulfoxides". . p. 406 - 421. Retrieved 2007/10/02.
• 2、 -. "Optically active salt of protected D-penicillamine and L-lysine". . . Retrieved 2008/06/13.