Benzoic acid, 2-[[4-hydroxy-3-(trifluoromethyl)phenyl]amino]-

Base Information

• Chemical Name: Benzoic acid, 2-[[4-hydroxy-3-(trifluoromethyl)phenyl]amino]-
• CAS No.: 39062-72-1
• Molecular Formula: C14H10 F3 N O3
• Molecular Weight: 297.23
• Hs Code.: 2922509090
• Mol file: 39062-72-1.mol

Synonyms:4'-Hydroxyflufenamicacid

Chemical Property of Benzoic acid, 2-[[4-hydroxy-3-(trifluoromethyl)phenyl]amino]-

Chemical Property:

• Vapor Pressure: 8.27E-07mmHg at 25°C
• Boiling Point: 390.8°Cat760mmHg
• PKA: 3?+-.0.36(Predicted)
• Flash Point: 190.2°C
• PSA: 69.56000
• Density: 1.486g/cm³
• LogP: 3.92580

Purity/Quality:

BENZOIC ACID, 2-[[4-HYDROXY-3-(TRIFLUOROMETHYL)PHENYL]AMINO]- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-[[4-hydroxy-3-(trifluoromethyl)phenyl]amino]-

There total 6 articles about Benzoic acid, 2-[[4-hydroxy-3-(trifluoromethyl)phenyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4'-Benzyloxy-flufenaminsaeure (39062-71-0) → 4'-Hydroxyflufenaminsaeure (39062-72-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

4-benzyloxy-3-trifluoromethyl-nitrobenzene (39062-69-6) → 4'-Hydroxyflufenaminsaeure (39062-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 98.8 percent / H₂ / Pt

2: 66 percent / K₂CO₃ / Cu powder / 2 h / 160 °C

3: 87 percent / H₂ / 10percent Pd/C / methanol

With hydrogen; potassium carbonate; palladium on activated charcoal; copper; platinum; In methanol;

Reference yield:

4-chloro-3-(trifluoromethyl)nitrobenzene (777-37-7) → 4'-Hydroxyflufenaminsaeure (39062-72-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / benzyltributylammonium bromide, NaOH / 24 h / 55 °C

2: 98.8 percent / H₂ / Pt

3: 66 percent / K₂CO₃ / Cu powder / 2 h / 160 °C

4: 87 percent / H₂ / 10percent Pd/C / methanol

With sodium hydroxide; hydrogen; benzyl tri-n-butylammonium bromide; potassium carbonate; palladium on activated charcoal; copper; platinum; In methanol;

upstream raw materials:

4'-Benzyloxy-flufenaminsaeure

4-benzyloxy-3-trifluoromethyl-nitrobenzene

4-chloro-3-(trifluoromethyl)nitrobenzene

3-(trifluoromethyl)-4-(benzyloxy)aniline

Refernces