2-(benzyloxy)-6-bromoquinoline

Base Information

• Chemical Name: 2-(benzyloxy)-6-bromoquinoline
• CAS No.: 300811-62-5
• Molecular Formula: C₁₆H₁₂BrNO
• Molecular Weight: 314.181
• Mol file: 300811-62-5.mol

Synonyms:2-(benzyloxy)-6-bromoquinoline

Chemical Property of 2-(benzyloxy)-6-bromoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-6-bromoquinoline

There total 3 articles about 2-(benzyloxy)-6-bromoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

6-bromoquinoline-2-ol (1810-66-8) + benzyl bromide (100-39-0) → 2-(benzyloxy)-6-bromoquinoline (300811-62-5)

Guidance literature:

With silver carbonate; In chloroform; for 48h;

DOI:10.1021/ol006366y

Reference yield:

6-bromo-2-quinolone (1810-66-8) + benzyl bromide (100-39-0) → 2-(benzyloxy)-6-bromoquinoline (300811-62-5)

Guidance literature:

With silver carbonate; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2013.12.048

Reference yield:

6-bromo-2-chloroquinoline (1810-71-5) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-6-bromoquinoline (300811-62-5)

Guidance literature:

With sodium hydride; at 120 ℃; for 16h;

upstream raw materials:

6-bromoquinoline-2-ol

benzyl bromide

6-bromo-2-quinolone

6-bromo-2-chloroquinoline

Downstream raw materials:

C₄₂H₃₁BrN₂O₂

C₄₂H₃₂N₂O₂

2-benzyloxy-6-quinolinecarboxaldehyde

Refernces

• 1、 Vidadala, Rama Subba Rao,Ojo, Kayode K.,Johnson, Steven M.,Zhang, Zhongsheng,Leonard, Stephen E.,Mitra, Arinjay,Choi, Ryan,Reid, Molly C.,Keyloun, Katelyn R.,Fox, Anna M.W.,Kennedy, Mark,Silver-Brace, Tiffany,Hume, Jen C.C.,Kappe, Stefan,Verlinde, Christophe L.M.J.,Fan, Erkang,Merritt, Ethan A.,Van Voorhis, Wesley C.,Maly, Dustin J.. "Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes". supporting information. p. 562 - 573. Retrieved 2014/03/21.