METHYL 3,5-DI-TERT-BUTYLSALICYLATE

Base Information

• Chemical Name: METHYL 3,5-DI-TERT-BUTYLSALICYLATE
• CAS No.: 15018-03-8
• Molecular Formula: C16H24 O3
• Molecular Weight: 264.365
• Hs Code.: 2918290000
• Mol file: 15018-03-8.mol

Synonyms:Salicylicacid, 3,5-di-tert-butyl-, methyl ester (8CI); Methyl3,5-di-tert-butyl-2-hydroxybenzoate; Methyl 3,5-di-tert-butylsalicylate

Chemical Property of METHYL 3,5-DI-TERT-BUTYLSALICYLATE

Chemical Property:

• Vapor Pressure: 0.000168mmHg at 25°C
• Melting Point: 74 °C
• Boiling Point: 320.5°C at 760 mmHg
• PKA: 11.36±0.23(Predicted)
• Flash Point: 118.6°C
• PSA: 46.53000
• Density: 1.02g/cm³
• LogP: 3.77380

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl3,5-Di-tert-butylsalicylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3,5-DI-TERT-BUTYLSALICYLATE

There total 6 articles about METHYL 3,5-DI-TERT-BUTYLSALICYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl alcohol (75-65-0) + methyl salicylate (119-36-8,8024-54-2) → methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate (15018-03-8)

Guidance literature:

With sulfuric acid; In methanol; at 20 ℃; for 5h;

DOI:10.1080/00397910701411077

Reference yield: 72.0%

3,5-ditertbutyl salicylic acid (19715-19-6) + temozolomide (85622-93-1) → methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate (15018-03-8)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 60 ℃; for 6h; Sealed tube;

DOI:10.1002/anie.201911896

Reference yield: 63.2%

tert-butyl alcohol (75-65-0) + methyl salicylate (119-36-8,8024-54-2) → methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate (15018-03-8) + 5-(tert-butyl)-2-hydroxybenzoic acid methyl ester (52888-72-9)

Guidance literature:

With sulfuric acid; In methanol; at -3.4 - 30 ℃;

upstream raw materials:

tert-butyl alcohol

methyl salicylate

isobutene

3,5-ditertbutyl salicylic acid

Refernces

• 1、 Jimenez, Claudio A.,Belmar, Julio B.. "Convenient and efficient method for the obtainment of ketones from highly hindered aromatic N,N-dimethyl-amides". . p. 2391 - 2397. Retrieved 2007.
• 2、 Monkcom, Emily C.,de Bruin, Dani?l,de Vries, Annemiek J.,Lutz, Martin,Ye, Shengfa,Klein Gebbink, Robertus J. M.. "Structurally Modelling the 2-His-1-Carboxylate Facial Triad with a Bulky N,N,O Phenolate Ligand". . p. 5191 - 5204. Retrieved 2021.
• 3、 Budri, Mahantesh,Vadavi, Ramesh,Kadolkar, Prajakta,Patil, Shivaraj,Gudasi, Kalagouda,Inamdar, Sanjeev. "Selective and sensitive optical probe for the recognition of Zn (II) ion through turn-on optical response in aqueous medium: Experimental and theoretical approach". . . Retrieved 2021.