Technology Process of lapatinib monohydrochloride
There total 8 articles about lapatinib monohydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
3: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 - 25 °C
4: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
5: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
6: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
With
methanol; sodium tris(acetoxy)borohydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); triphenyl-arsane;
In
dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: trifluoroacetic acid / toluene / 110 - 115 °C / Molecular sieve; Inert atmosphere
2: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
4: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 - 25 °C
5: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
6: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
7: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
With
methanol; sodium tris(acetoxy)borohydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); triphenyl-arsane;
In
dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
