4-ETHYLSULFONYL-2-NITROANISOLE

Base Information

• Chemical Name: 4-ETHYLSULFONYL-2-NITROANISOLE
• CAS No.: 51572-44-2
• Molecular Formula: C₉H₁₁NO₅S
• Molecular Weight: 245.256
• Mol file: 51572-44-2.mol

Synonyms:4-(ethylsulfonyl)-1-methoxy-2-nitrobenzene

Chemical Property of 4-ETHYLSULFONYL-2-NITROANISOLE

Chemical Property:

• Melting Point: 116-118°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Ethylsulfonyl-2-nitroanisole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-ETHYLSULFONYL-2-NITROANISOLE

There total 5 articles about 4-ETHYLSULFONYL-2-NITROANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(ethylsulfonyl)-4-methoxybenzene (7205-79-0) → 4-(ethylsulfonyl)-1-methoxy-2-nitrobenzene (51572-44-2)

Guidance literature:

With nitric acid; at 70 ℃; Temperature;

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → 4-(ethylsulfonyl)-1-methoxy-2-nitrobenzene (51572-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; sodium sulfite / water; tetrahydrofuran / 0 - 20 °C

2: methanol / 2.16 h / Reflux; Inert atmosphere

3: nitric acid / 2 h / 100 °C

With nitric acid; sodium hydrogencarbonate; sodium sulfite; In tetrahydrofuran; methanol; water;

DOI:10.3762/bjoc.9.20

Reference yield:

sodium 4-methoxybenzenesulfinate (6462-50-6) → 4-(ethylsulfonyl)-1-methoxy-2-nitrobenzene (51572-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2.16 h / Reflux; Inert atmosphere

2: nitric acid / 2 h / 100 °C

With nitric acid; In methanol;

DOI:10.3762/bjoc.9.20

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

sodium 4-methoxybenzenesulfinate

1-(ethylsulfonyl)-4-methoxybenzene

methoxybenzene

Downstream raw materials:

5-(ethylsulfonyl)-2-methoxy-1,3-dinitrobenzene

3-amino-4-methoxyphenylethyl sulfone

4-(ethylsulfonyl)-2-nitro-phenol

2-amino-4-(ethylsulfonyl)phenol

Refernces

• 1、 Murar, Miroslav,Addova, Gabriela,Bohac, Andrej. "Synthesis of 5-(ethylsulfonyl)-2-methoxyaniline: An important pharmacological fragment of VEGFR2 and other inhibitors". . p. 173 - 179. Retrieved 2013/03/29.