C₂₆H₃₉N₅O₄

Base Information

• Chemical Name: C₂₆H₃₉N₅O₄
• CAS No.: 1349554-82-0
• Molecular Formula: C₂₆H₃₉N₅O₄
• Molecular Weight: 485.627
• Mol file: 1349554-82-0.mol

Synonyms:C₂₆H₃₉N₅O₄

Chemical Property of C₂₆H₃₉N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₉N₅O₄

There total 7 articles about C₂₆H₃₉N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H39N5O5 → C26H39N5O4 (1349554-82-0)

Guidance literature:

C₂₆H₃₉N₅O₅; With acetic anhydride; In acetic acid; for 0.5h;

With palladium 10% on activated carbon; hydrogen; In acetic acid; for 12h;

With hydrogenchloride; In methanol; acetic acid; at 0 ℃; for 3h;

DOI:10.1016/j.ejmech.2015.03.059

Reference yield:

C34H45N5O6 (162696-40-4) → C26H39N5O4 (1349554-82-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 18h;

DOI:10.1021/jm9016416

Reference yield:

tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate (171846-10-9) → C26H39N5O4 (1349554-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / methanol / 16 h

2.1: acetic anhydride / acetic acid / 0.5 h

2.2: 12 h

2.3: 3 h / 0 °C

With hydroxylamine hydrochloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; In methanol; acetic acid;

DOI:10.1016/j.ejmech.2015.03.059

upstream raw materials:

C₃₄H₄₅N₅O₆

tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate

1-(tert-butoxycarbonyl)-L-proline

4-cyanobenzylamine hydrochloride

Refernces

• 1、 Muley, Laveena,Baum, Bernhard,Smolinski, Michael,Freindorf, Marek,Heine, Andreas,Klebe, Gerhard,Hangauer, David G.. "Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: Synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors". supporting information; experimental part. p. 2126 - 2135. Retrieved 2010/08/19.