(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane

Base Information

• Chemical Name: (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane
• CAS No.: 1163701-10-7
• Molecular Formula: C₁₇H₁₆O₂S
• Molecular Weight: 284.379
• Mol file: 1163701-10-7.mol

Synonyms:(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane

Chemical Property of (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane

There total 6 articles about (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

dimethylsulfide (75-18-3) + 2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene (1163700-92-2) → (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane (1163701-10-7)

Guidance literature:

2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1.5h; Inert atmosphere;

dimethylsulfide; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/co200090p

Reference yield: 64.0%

Dimethyldisulphide (624-92-0) + 2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene (1163700-92-2) → (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane (1163701-10-7)

Guidance literature:

2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Dimethyldisulphide; In tetrahydrofuran; at -78 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/co500115b

Reference yield:

3-bromo-4-iodoanisole (466639-53-2) → (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane (1163701-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 50 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; cyclohexane; 1.1: Sonogashira reaction;

DOI:10.1021/co200090p

upstream raw materials:

3-bromo-4-iodoanisole

dimethylsulfide

2-bromo-4-methoxy-1-((4-methoxyphenyl)ethynyl)benzene

4-methoxyphenylacetylen

Downstream raw materials:

C₂₂H₁₈O₃S

C₂₇H₂₆O₄S

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Refernces

• 1、 Cho, Chul-Hee,Jung, Dai-Il,Neuenswander, Benjamin,Larock, Richard C.. "Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling". . p. 501 - 510. Retrieved 2011/10/31.