N-(2-amino-2-oxoethyl)benzamide

Base Information

• Chemical Name: N-(2-amino-2-oxoethyl)benzamide
• CAS No.: 5813-81-0
• Molecular Formula: C9H10 N2 O2
• Molecular Weight: 178.191
• Mol file: 5813-81-0.mol

Synonyms:Benzamide,N-(carbamoylmethyl)- (5CI); Hippuramide (6CI,7CI,8CI); Hippuric acid amide;Hippurimidic acid; Hippurylamide; N-Benzoylglycinamide; NSC 43239

Chemical Property of N-(2-amino-2-oxoethyl)benzamide

Chemical Property:

• Vapor Pressure: 9.59E-10mmHg at 25°C
• Boiling Point: 489.9°Cat760mmHg
• Flash Point: 250.1°C
• Density: 1.211g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-amino-2-oxoethyl)benzamide

There total 16 articles about N-(2-amino-2-oxoethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) → hippuramide (5813-81-0)

Guidance literature:

With silica gel; ammonium chloride; triethylamine; p-toluenesulfonyl chloride; at 20 ℃; for 0.0166667h;

DOI:10.1016/j.tetlet.2005.08.021

Reference yield: 79.0%

thiobenzoic acid (98-91-9) + H-Gly-NH2 (598-41-4) → hippuramide (5813-81-0)

Guidance literature:

With oxygen; 3,6-di(2'-pyridyl)-1,2,4,5-tetrazine; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2020.152272

Reference yield: 72.0%

Bz-Gly-Thr-OMe (115494-73-0) → hippuramide (5813-81-0)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; for 8h; Ambient temperature; pH 3;

DOI:10.1021/ja00094a008

upstream raw materials:

Hippuric Acid

methyl hippurate

ethyl hippurate

hippuramidine

Downstream raw materials:

Benzotriazol-1-yl-(2-benzoylamino-acetylamino)-acetic acid ethyl ester

N-[(1-Benzotriazol-1-yl-2-methyl-propylcarbamoyl)-methyl]-benzamide

α-benzoylaminocinnamic acid amide

N-{[(Amino-carbamoyl-methyl)-carbamoyl]-methyl}-benzamide

Refernces

• 1、 Samanta, Suvendu,Ray, Shounak,Bhaduri, Samanka Narayan,Samanta, Partha Kumar,Biswas, Papu. "3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine (pytz) catalysed metal-free amide bond formation from thioacids and amines at room temperature". supporting information. . Retrieved 2020/08/10.
• 2、 Shafi,Sobha. "A new synthetic route to 4-arylidene-2-phenyl-2-imidazolin-5-ones". . p. 378 - 379. Retrieved 2007/10/03.