5-acetoxy-7,4′-dimethoxyflavanone

Base Information

• Chemical Name: 5-acetoxy-7,4′-dimethoxyflavanone
• CAS No.: 81148-82-5
• Molecular Formula: C₁₉H₁₈O₆
• Molecular Weight: 342.348
• Mol file: 81148-82-5.mol

Synonyms:5-acetoxy-7,4′-dimethoxyflavanone

Chemical Property of 5-acetoxy-7,4′-dimethoxyflavanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetoxy-7,4′-dimethoxyflavanone

There total 6 articles about 5-acetoxy-7,4′-dimethoxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

naringenin-4',7-dimethyl ether (29424-96-2,102101-05-3,120851-84-5,137329-43-2,13238-06-7) + acetyl chloride (75-36-5) → 5-acetoxy-7,4′-dimethoxyflavanone (81148-82-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1039/c7ob01004d

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 5-acetoxy-7,4′-dimethoxyflavanone (81148-82-5)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetone / Reflux

2: barium(II) hydroxide / ethanol / 2 h / 40 °C

3: sodium acetate / ethanol / Reflux

4: aluminum (III) chloride / acetonitrile / 1 h / Reflux

5: dmap; triethylamine / dichloromethane / 0.17 h / 20 °C

With dmap; aluminum (III) chloride; sodium acetate; potassium carbonate; triethylamine; barium(II) hydroxide; In ethanol; dichloromethane; acetone; acetonitrile;

DOI:10.1039/c7ob01004d

Reference yield:

flavokawain A (3420-72-2) → 5-acetoxy-7,4′-dimethoxyflavanone (81148-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate / ethanol / Reflux

2: aluminum (III) chloride / acetonitrile / 1 h / Reflux

3: dmap; triethylamine / dichloromethane / 0.17 h / 20 °C

With dmap; aluminum (III) chloride; sodium acetate; triethylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1039/c7ob01004d

upstream raw materials:

2,4,6-trihydroxyacetophenone

2-hydroxy-4,6-dimethoxyacetophenone

4',5,7-trimethoxyflavanone

naringenin-4',7-dimethyl ether

Downstream raw materials:

7,4'-di-O-methylapigenin 5-O-1-β-xylopyranosyl(1->6)-β-glucopyranoside

Refernces