3-Methylthio-1,2,4-triazine

Base Information

• Chemical Name: 3-Methylthio-1,2,4-triazine
• CAS No.: 28735-21-9
• Molecular Formula: C4H5N3S
• Molecular Weight: 127.17
• Hs Code.: 2933698090
• Mol file: 28735-21-9.mol

Synonyms:3-Methylthio-1,2,4-triazine;NSC 276290;

Chemical Property of 3-Methylthio-1,2,4-triazine

Chemical Property:

• Vapor Pressure: 0.0084mmHg at 25°C
• Melting Point: 33 °C
• Refractive Index: 1.577
• Boiling Point: 275.754 °C at 760 mmHg
• PKA: 1.32±0.63(Predicted)
• Flash Point: 120.572 °C
• PSA: 63.97000
• Density: 1.287 g/cm³
• LogP: 0.59350
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Methylthio)-as-triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methylthio-1,2,4-triazine

There total 7 articles about 3-Methylthio-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 3-methylthio-1,2,4-triazine (28735-21-9)

Guidance literature:

With sodium hydrogencarbonate; In water; at 0 - 20 ℃; for 18h;

Reference yield: 99.0%

Glyoxal (131543-46-9,107-22-2) + S-methylisothiosemicarbazide hydroiodide (35600-34-1) → 3-methylthio-1,2,4-triazine (28735-21-9)

Guidance literature:

In ethanol; water; for 16h; Ambient temperature;

DOI:10.1021/jo00297a050

Reference yield: 93.0%

S-methylisothiosemicarbazide hydroiodide (35600-34-1) → 3-methylthio-1,2,4-triazine (28735-21-9)

Guidance literature:

With sodium hydrogencarbonate; In water; at 0 ℃; for 18h;

DOI:10.1002/ejoc.201600267

upstream raw materials:

Glyoxal

S-methyl isothiosemicarbazide hydroiodide

S-methylisothiosemicarbazide hydroiodide

hydrazinyl(methylthio)methanamine

Downstream raw materials:

3-Pyrrolidino-1,2,4-triazine

4-Methylsulfanyl-2-phenyl-pyrrolo[3,4-c]pyridine-1,3-dione

3-Acetyl-5-methylsulfanyl-1-phenyl-1,3,3a,4,7,7a-hexahydro-1,4,6,7-tetraaza-inden-2-one; compound with trifluoro-acetic acid

N-methyl-1,2,4-triazin-3-amine

Refernces

• 1、 -. "1,3,4-Thiadiazole Compounds and Their Use in Treating Cancer". Paragraph 0294; 0295. . Retrieved 2017/06/30.
• 2、 -. "1, 3, 4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER". Page/Page column 78. . Retrieved 2016/02/26.