Normorphine

Base Information Edit

Chemical Name:Normorphine
CAS No.:466-97-7
Molecular Formula:C₁₆H₁₇NO₃
Molecular Weight:271.316
Hs Code.:2939190023
European Community (EC) Number:207-381-4
UNII:XUI1Y24IMI
Nikkaji Number:J5.905F
Wikipedia:Normorphine
Wikidata:Q4327449
NCI Thesaurus Code:C170234
Pharos Ligand ID:8USCBD6W6YPH
ChEMBL ID:CHEMBL1227
Mol file:466-97-7.mol

Synonyms:(-)-normorphine;(5alpha,6alpha)-7,8-didehydro-4,5-epoxymorphinan-3,6-diol hydrochloride;4,5-epoxy-3,6-dihydroxymorphin-7-ene;desmethylmorphine;morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-;n-demethylmorphine;normorphine;normorphine hydrochloride;normorphine perchlorate;normorphine sulfamate

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Normorphine Edit

Chemical Property:

Vapor Pressure:2.99E-10mmHg at 25°C
Melting Point:276-2770C
Refractive Index:1.5500 (estimate)
Boiling Point:485.8°C at 760 mmHg
PKA:pKa 8.66±0.01;9.80± 0.01(H2O,t =25,I=0.15(KCl)Ar)(Approximate)
Flash Point:247.6°C
PSA：61.72000
Density:1.48g/cm³
LogP:1.18470
Storage Temp.:Controlled Substance, -20°C Freezer
XLogP3:0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:271.12084340
Heavy Atom Count:20
Complexity:467

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:T+,T,F
Statements: 26/27/28-39/23/24/25-23/24/25-11
Safety Statements: 53-36/37-45-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CNC2CC3=C4C15C2C=CC(C5OC4=C(C=C3)O)O
Isomeric SMILES:C1CN[C@@H]2CC3=C4[C@@]15[C@H]2C=C[C@@H]([C@@H]5OC4=C(C=C3)O)O
Uses A metabolite of Codeine. This is a controlled substance (opium derivative). Analgesic (narcotic) Normorphine is a metabolite of Morphine (M652290). This is a controlled substance (opium derivative). Analgesic (narcotic).

Technology Process of Normorphine

There total 21 articles about Normorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: C₂₀H₂₁NO₅*(x)ClH

: 466-97-7,13396-02-6,99295-16-6,142864-36-6
normorphine

Guidance literature:: C₂₀H₂₁NO₅*(x)ClH; With hydrogenchloride; at 100 ℃; for 4h;

With ammonia; pH=9 - 10;
DOI:10.3390/molecules25174009

Reference yield: 63.0%

: 1234788-64-7
morphine-N-oxide hydrochloride

: 466-97-7,13396-02-6,99295-16-6,142864-36-6
normorphine

: 57-27-2
MORPHIN

Guidance literature:: morphine-N-oxide hydrochloride; With ferrocene; In isopropyl alcohol; at 40 ℃; for 120h;

With ammonium hydroxide; In dichloromethane; water; isopropyl alcohol; pH=8;
DOI:10.1016/j.bmcl.2010.06.031