N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide

Base Information

• Chemical Name: N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide
• CAS No.: 25713-24-0
• Molecular Formula: C₁₁H₂₀IN₂O₂
• Molecular Weight: 339.196
• Hs Code.: 29339980
• European Community (EC) Number: 806-307-3
• DSSTox Substance ID: DTXSID30180405
• Nikkaji Number: J541.166A
• Mol file: 25713-24-0.mol

Synonyms:2,2,6,6-tetramethylpiperdin-N-1-oxyiodoacetamide;4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl;4-(N-iodoacetamide)-2,2,6,6-tetramethylpiperidine-1-oxyl;IASL;N-(1-oxy-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide;N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide;N-(oxyl-2,2,6,6-tetramethylpiperid-4-yl)iodoacetamide;TMPIA

Chemical Property of N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide

Chemical Property:

• Vapor Pressure: 1.49E-08mmHg at 25°C
• Melting Point: 114-117 °C
• Boiling Point: 428.8°Cat760mmHg
• Flash Point: 213.1°C
• PSA: 32.34000
• Density: 1.53g/cm³
• LogP: 2.23350
• Storage Temp.: 0-6°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 339.05695
• Heavy Atom Count: 16
• Complexity: 261

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Iodoacetamido)-TEMPO ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 24/25-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(CC(N1[O])(C)C)NC(=O)CI)C
• Uses: 4-(2-Iodoacetamido)-TEMPO is a methionine specific spin label that is used to investigate the binding site of phosphoenolpyruvate caboxykinase and GTP, as well as evaluate the alkylation of SH1 and SH2 of myosin.

Technology Process of N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide

There total 1 articles about N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-(α)-iodoacetamido-2,2,6,6-tetramethylpiperidino-1-oxy (25713-24-0)

Guidance literature:

Chloracetamidoverbdg. VIII, NaI;

DOI:10.1007/BF00481109

Reference yield: 50.0%

4-(α)-iodoacetamido-2,2,6,6-tetramethylpiperidino-1-oxy (25713-24-0) + C33H40N3(1+)*2F6P(1-)*H(1+) → C44H60N5O2(2+)*3F6P(1-)*H(1+)

Guidance literature:

With ammonium hexafluorophosphate; In acetonitrile; for 18h; Reflux;

DOI:10.1002/open.201402073

Reference yield: 30.0%

C35H50NO11 + 4-(α)-iodoacetamido-2,2,6,6-tetramethylpiperidino-1-oxy (25713-24-0) + C33H40N3(1+)*2F6P(1-)*H(1+) → C35H52NO11*C44H60N5O2(2+)*3F6P(1-)*H(1+)

Guidance literature:

With ammonium hexafluorophosphate; In chloroform; for 96h; Reflux;

DOI:10.1002/open.201402073