valyltyrosylproline tert-butyl ester

Base Information

• Chemical Name: valyltyrosylproline tert-butyl ester
• CAS No.: 3080-65-7
• Molecular Formula: C₂₃H₃₅N₃O₅
• Molecular Weight: 433.548
• Mol file: 3080-65-7.mol

Synonyms:valyltyrosylproline tert-butyl ester

Chemical Property of valyltyrosylproline tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of valyltyrosylproline tert-butyl ester

There total 4 articles about valyltyrosylproline tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ZValTyrProOtBu (3271-52-1) → valyltyrosylproline tert-butyl ester (3080-65-7)

Guidance literature:

With hydrogen; palladium; In methanol;

DOI:10.1007/BF00579967

Reference yield:

proline tert-butyl ester (2812-46-6) → valyltyrosylproline tert-butyl ester (3080-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, conc.HCl, 2.) triethylamine / 1.) CH₃OH, -5 deg C, 20 min, 2.) CH₂Cl₂, 0 deg C, 7 h, 17 - 20 deg C, 72 h

2: 100 percent / H₂ / Pd / methanol

With hydrogenchloride; hydrogen; triethylamine; sodium nitrite; palladium; In methanol;

DOI:10.1007/BF00579967

Reference yield:

N-benzyloxycarbonylvalyltyrosine hydrazide (5992-90-5) → valyltyrosylproline tert-butyl ester (3080-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, conc.HCl, 2.) triethylamine / 1.) CH₃OH, -5 deg C, 20 min, 2.) CH₂Cl₂, 0 deg C, 7 h, 17 - 20 deg C, 72 h

2: 100 percent / H₂ / Pd / methanol

With hydrogenchloride; hydrogen; triethylamine; sodium nitrite; palladium; In methanol;

DOI:10.1007/BF00579967

upstream raw materials:

ZValTyrProOtBu

N-benzyloxycarbonylvalyltyrosine hydrazide

N^α-benzyloxycarbonylvalyltyrosine

proline tert-butyl ester

Downstream raw materials:

N^α-benzyloxycarbonylvalyl-N^ε-tert-butoxycarbonyllysylvalyltyrosylproline tert-butyl ester

H-ValLys(BOC)ValTyrPro-OtBu

Refernces