2-Amino-9-fluorenone

Base Information

• Chemical Name: 2-Amino-9-fluorenone
• CAS No.: 3096-57-9
• Molecular Formula: C13H9 N O
• Molecular Weight: 195.221
• Hs Code.: 29223990
• European Community (EC) Number: 221-445-9
• NSC Number: 12368
• UNII: GZ78W0R94U
• DSSTox Substance ID: DTXSID30184943
• Nikkaji Number: J69.720F
• Wikidata: Q83055885
• ChEMBL ID: CHEMBL1698358
• Mol file: 3096-57-9.mol

Synonyms:2-Amino-9-fluorenone;3096-57-9;2-Amino-9H-fluoren-9-one;2-Aminofluoren-9-one;2-Aminofluorenone;9H-Fluoren-9-one, 2-amino-;FLUOREN-9-ONE, 2-AMINO-;EINECS 221-445-9;NSC 12368;9H-Fluoren-9-one, 2-amino- (9CI);BRN 2804184;AI3-23895;GZ78W0R94U;NSC-12368;4-14-00-00306 (Beilstein Handbook Reference);2-Amino-fluorenon;NSC12368;2-Aminofluorenone-9;2-aminofluorene-9-one;2-amino-fluoren-9-one;UNII-GZ78W0R94U;Oprea1_751887;MLS001180163;SCHEMBL760965;2-Amino-9-fluorenone, 98%;2-Amino-9H-fluoren-9-one #;CHEMBL1698358;SJODITPGMMSNRF-UHFFFAOYSA-;DTXSID30184943;HMS2778A19;MFCD00001157;AKOS015855592;AS-58758;LS-69307;SMR000476296;A1040;FT-0634661;A820672;AG-690/32513036;J-018206

Chemical Property of 2-Amino-9-fluorenone

Chemical Property:

• Appearance/Colour: red to brown crystalline powder
• Vapor Pressure: 1.77E-07mmHg at 25°C
• Melting Point: 152 - 157 C
• Refractive Index: 1.6060 (estimate)
• Boiling Point: 426.4°Cat760mmHg
• PKA: 3.06±0.20(Predicted)
• Flash Point: 211.7°C
• PSA: 43.09000
• Density: 1.327g/cm³
• LogP: 3.06140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: almost transparency in hot Methanol
• Water Solubility.: Soluble in alcohol and ether. Insoluble in water.
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.068413911
• Heavy Atom Count: 15
• Complexity: 276

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-9-fluorenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(C2=O)C=C(C=C3)N
• Uses: 2-Amino-9-fluorenone is used as an active pharmaceutical intermediate.

Technology Process of 2-Amino-9-fluorenone

There total 10 articles about 2-Amino-9-fluorenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminofluorene (153-78-6) → 2-amino-9-fluorenone (3096-57-9)

Guidance literature:

With manganese(IV) oxide; caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 8h; Reagent/catalyst; Time;

Reference yield: 91.0%

2-nitro-9H-fluoren-9-one (3096-52-4) → 2-amino-9-fluorenone (3096-57-9)

Guidance literature:

With hydrogen; In water; at 120 ℃; for 5h; under 15001.5 Torr; chemoselective reaction; Green chemistry;

DOI:10.1002/cssc.201901867

Reference yield:

2-bromofluoren-9-one (3096-56-8) → 2-amino-9-fluorenone (3096-57-9)

Guidance literature:

With ammonia; copper(l) chloride; at 200 ℃;

upstream raw materials:

2-nitro-9H-fluoren-9-one

2-bromofluoren-9-one

2-aminofluorene

ethanol

Downstream raw materials:

2-Ethoxycarbonylmethylamino-3-brom-fluorenon

3-Brom-2-N-<2-(4-brom-phenyl)-2-oxo-ethyl>-amino-fluorenon

4'-aminobiphenyl-2-carboxylic acid

2-(N-benzyloxycarbonyl)amino-9-fluorenone

Refernces

• 1、 Koohestani, Fatemeh,Sadjadi, Samahe. "Palladated composite of Cu-BDC MOF and perlite as an efficient catalyst for hydrogenation of nitroarenes". . . Retrieved 2021/11/04.
• 2、 Duan, Yanan,Dong, Xiaosu,Song, Tao,Wang, Zhaozhan,Xiao, Jianliang,Yuan, Youzhu,Yang, Yong. "Hydrogenation of Functionalized Nitroarenes Catalyzed by Single-Phase Pyrite FeS2 Nanoparticles on N,S-Codoped Porous Carbon". . . Retrieved 2019/09/13.