1,2-Dimorpholinoethane

Base Information

• Chemical Name: 1,2-Dimorpholinoethane
• CAS No.: 1723-94-0
• Molecular Formula: C10H20 N2 O2
• Molecular Weight: 200.281
• Hs Code.: 2934999090
• European Community (EC) Number: 217-026-5
• NSC Number: 4514
• UNII: FX7MP8BZX9
• DSSTox Substance ID: DTXSID9061914
• Nikkaji Number: J203.119A
• Wikidata: Q81989746
• ChEMBL ID: CHEMBL3408516
• Mol file: 1723-94-0.mol

Synonyms:1,2-Dimorpholinoethane;1723-94-0;4,4'-Ethylenedimorpholine;4-(2-morpholin-4-ylethyl)morpholine;4,4'-(Ethane-1,2-diyl)bismorpholine;Morpholine, 4,4'-(1,2-ethanediyl)bis-;1,2-Di-N-morpholinylethane;Morpholine,4,4'-(1,2-ethanediyl)bis-;Morpholine, 4,4'-ethylenedi-;NSC 4514;NSC-4514;EINECS 217-026-5;4-[2-(4-morpholinyl)ethyl]morpholine;4,4/'-(ethane-1,2-diyl)bismorpholine;NSC4514;FX7MP8BZX9;Morpholine,4'-ethylenedi-;SCHEMBL235080;4-(2-morpholinoethyl)morpholine;CHEMBL3408516;DTXSID9061914;AKOS003294809;Morpholine,4'-(1,2-ethanediyl)bis-;AF-960/00448017

Chemical Property of 1,2-Dimorpholinoethane

Chemical Property:

• Melting Point: 75°C
• Refractive Index: 1.4710 (estimate)
• Boiling Point: 276.2°Cat760mmHg
• PKA: 7.52±0.10(Predicted)
• Flash Point: 79.6°C
• PSA: 24.94000
• Density: 1.05g/cm³
• LogP: -0.47340
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 200.152477885
• Heavy Atom Count: 14
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

4-[2-(MORPHOLIN-4-YL)ETHYL]MORPHOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C1COCCN1CCN2CCOCC2

Technology Process of 1,2-Dimorpholinoethane

There total 15 articles about 1,2-Dimorpholinoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

morpholine (110-91-8,99108-56-2) + ethylene dibromide (106-93-4) → 1,2-dimorpholylethane (1723-94-0)

Guidance literature:

for 5.5h; Reflux;

DOI:10.1002/ejoc.201600453

Reference yield: 76.0%

1,2-bis(1H-benzo[d][1,2,3]triazol-1-yl)-1,2-dimorpholinoethane (151257-53-3) → 1,2-dimorpholylethane (1723-94-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo00297a042

Reference yield: 70.0%

morpholine (110-91-8,99108-56-2) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1,2-dimorpholylethane (1723-94-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; at 70 - 80 ℃;

DOI:10.1134/S1070363212020302

upstream raw materials:

morpholine

N-(2-chlorethyl)morpholine

ethylene dibromide

2,2',2'',2'''-ethane-1,2-diylbisazanediyl-tetrakis-ethanol

Downstream raw materials:

4-morpholinecarboxaldehyde

3,12-dioxa-6,9-diazonia-dispiro[5.2.5.3]heptadecane; dibromide

Refernces

• 1、 Markosyan,Baghdasaryan,Oganesyan,Attaryan,Asratyan. "Phase-transfer catalyzed alkylation of morpholine with 1,2-dichloroethane". . p. 344 - 345. Retrieved 2012.
• 2、 Zhao, Yaohong,Cai, Shunyou,Li, Jing,Wang, David Zhigang. "Visible-light photo-catalytic C-C bond cleavages: Preparations of N,N-dialkylformamides from 1,2-vicinal diamines". supporting information. p. 8129 - 8131. Retrieved 2013/08/28.