methylacetylphosphonate

Base Information

• Chemical Name: methylacetylphosphonate
• CAS No.: 40962-37-6
• Molecular Formula: C3H7 O5 P
• Molecular Weight: 154.059
• Hs Code.: 2931900090
• Mol file: 40962-37-6.mol

Synonyms:Aceticacid, phosphono-, 1-methyl ester (9CI); Phosphonic acid, methoxycarbonylmethyl-

Chemical Property of methylacetylphosphonate

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Boiling Point: 331.6°C at 760 mmHg
• Flash Point: 154.4°C
• PSA: 93.64000
• Density: 1.529g/cm³
• LogP: -0.66290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methylacetylphosphonate

There total 6 articles about methylacetylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Methyl diethylphosphonoacetate (1067-74-9) → phosphonoacetic acid trimethyl ester (40962-37-6)

Guidance literature:

Methyl diethylphosphonoacetate; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 12h;

With sodium methylate; In methanol; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/anie.201308363

Reference yield:

methanol (67-56-1) + ethyl P,P-bis(trimethylsilyl) phosphonoacetate (65868-40-8) → phosphonoacetic acid (4408-78-0) + phosphonoacetic acid ethyl ester (35752-46-6) + phosphonoacetic acid trimethyl ester (40962-37-6)

Guidance literature:

With water; at 20 ℃; for 18h;

DOI:10.3762/bjoc.16.119

Reference yield:

phosphonoacetic acid (4408-78-0) → phosphonoacetic acid trimethyl ester (40962-37-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol; P₂ O₅;

upstream raw materials:

Methyl diethylphosphonoacetate

trimethyl phosphonoacetate

methyl 2-(bis((trimethylsilyl)oxy)phosphoryl)acetate

phosphonoacetic acid

Downstream raw materials:

methyl 2-(4-(dimethylamino)-4-phenylcyclohexylidene)acetate

methyl 2-cyclobutylideneacetate

(E)-3-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acrylic acid methyl ester

bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate

Refernces

• 1、 Justyna, Katarzyna,Ma?olepsza, Joanna,Kusy, Damian,Maniukiewicz, Waldemar,B?a?ewska, Katarzyna M.. "The mckenna reaction – avoiding side reactions in phosphonate deprotection". . p. 1436 - 1446. Retrieved 2020/07/08.
• 2、 Gao, Jiangtao,Ju, Kou-San,Yu, Xiaomin,Velasquez, Juan E.,Mukherjee, Subha,Lee, Jaeheon,Zhao, Changming,Evans, Bradley S.,Doroghazi, James R.,Metcalf, William W.,Van Der Donk, Wilfred A.. "Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster". supporting information. p. 1334 - 1337. Retrieved 2014/03/21.