4-Ethoxybenzene-1,2-diamine

Base Information

• Chemical Name: 4-Ethoxybenzene-1,2-diamine
• CAS No.: 1197-37-1
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.196
• Hs Code.: 2922299090
• European Community (EC) Number: 214-825-0
• UNII: DA5O61D538
• DSSTox Substance ID: DTXSID6061608
• Nikkaji Number: J217.038H
• Wikidata: Q27276295
• Mol file: 1197-37-1.mol

Synonyms:4-Ethoxybenzene-1,2-diamine;1197-37-1;1,2-Benzenediamine, 4-ethoxy-;3,4-Diaminophenetole;1,2-Diamino-4-ethoxybenzene;4-Ethoxy-1,2-phenylenediamine;4-ETHOXY-1,2-BENZENEDIAMINE;o-Phenylenediamine, 4-ethoxy-;HSDB 6233;4-Ethoxybenzol-1,2-diamin;UNII-DA5O61D538;DA5O61D538;EINECS 214-825-0;4-Ethoxy-benzene-1,2-diamine;SCHEMBL5952240;DTXSID6061608;4-ETHOXY-O-PHENYLENEDIAMINE;BBL000365;MFCD00640896;STK513452;AKOS000107978;4-ethoxybenzene-1,2-diamine, AldrichCPR;VS-00594;4-ETHOXY-1,2-BENZENEDIAMINE [HSDB];BB 0244868;FT-0601102;EN300-1295534;A804347;Q27276295

Chemical Property of 4-Ethoxybenzene-1,2-diamine

Chemical Property:

• Vapor Pressure: 0.00157mmHg at 25°C
• Melting Point: 79-81℃
• Refractive Index: 1.6
• Boiling Point: 294.999 °C at 760 mmHg
• PKA: 4.82±0.10(Predicted)
• Flash Point: 163.802 °C
• PSA: 61.27000
• Density: 1.131 g/cm³
• LogP: 2.41210
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 152.094963011
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Ethoxybenzene-1,2-diamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aromatic
• Canonical SMILES: CCOC1=CC(=C(C=C1)N)N

Technology Process of 4-Ethoxybenzene-1,2-diamine

There total 14 articles about 4-Ethoxybenzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-4-ethoxyaniline (616-86-4) → 4-ethoxy-benzene-1,2-diamine (1197-37-1)

Guidance literature:

With ethanol; nickel; Hydrogenation;

Reference yield:

N-(4-ethoxy-2-nitrophenyl)acetamide (885-81-4) → 4-ethoxy-benzene-1,2-diamine (1197-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. HCl / 2 h / Heating

2: aq. hydrazine / Raney nickel / 5 h / 60 - 70 °C

With hydrogenchloride; hydrazine hydrate; nickel;

DOI:10.1007/BF00869526

Reference yield:

4-ethoxyacetanilide (62-44-2,105931-34-8) → 4-ethoxy-benzene-1,2-diamine (1197-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / nitric acid, aq. acetic acid / 0.17 h / 70 °C

2: 100 percent / H₂ / Pd/C / ethyl acetate

3: 20percent aq. KOH / 2 h / Heating

With potassium hydroxide; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm00350a002

upstream raw materials:

N-(2-amino-4-ethoxyphenyl)acetamide

2-nitro-4-ethoxyaniline

N-(4-ethoxy-2-nitrophenyl)acetamide

N,N'-(4-ethoxy-o-phenylene)-bis-acetamide

Downstream raw materials:

5-ethoxy-2-benzyl-1⁽³⁾H-benzimidazole

10-ethoxy-benzo[de]benz[4,5]imidazo[2,1-a]isoquinolin-7-one

11-ethoxy-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

5-ethoxy-1,3-dihydro-2H-benzo[d]imidazole-2-thione

Refernces

• 1、 -. "HEPATITIS C VIRUS INHIBITORS". . . Retrieved 2016/01/21.
• 2、 Rtishchev,Selitrennikov. "Phototransformations of 6-X-5-nitroquinoxalines". . p. 428 - 437. Retrieved 2007/10/03.