Technology Process of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-fluoro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide
There total 11 articles about 2,2,2-trifluoro-N-(4-fluoro-3-{1-[4-fluoro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: nitric acid; sulfuric acid / 1.17 h / 0 °C
1.2: 5 h / 2068.65 Torr
2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.17 h / -78 °C
2.2: 0.58 h / -78 °C
3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C
4.1: potassium hydroxide / tert-butyl alcohol / 6 h / 80 °C
5.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C
5.2: 4 h / 20 °C
6.1: N,N-dimethyl-formamide / 20 - 50 °C
7.1: sodium hydroxide / methanol / 1 h / 80 °C
7.2: pH 2
8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C
With
copper(l) iodide; sulfuric acid; sec.-butyllithium; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane; cyclohexane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr
2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C
With
hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
platinum on carbon;
In
methanol; dichloromethane;
