Technology Process of N-hydroxy-2-(2-(4'-((2-hydroxyethyl)amino)-[1,1'-biphenyl]-4-yl)quinolin-4-yl)acetamide
There total 6 articles about N-hydroxy-2-(2-(4'-((2-hydroxyethyl)amino)-[1,1'-biphenyl]-4-yl)quinolin-4-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C26H24N2O3;
With
hydroxylamine;
In
methanol; water;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
sodium hydroxide;
In
methanol; water;
at 0 - 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 1 h / Inert atmosphere; Reflux
1.2: 0.5 h / 0 °C / Inert atmosphere
2.1: silver benzoate; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 16 h / Inert atmosphere; Reflux
4.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere; Reflux
4.2: 12 h / Reflux
5.1: hydroxylamine / water; methanol / 0.17 h / 0 °C / Inert atmosphere
5.2: 2.5 h / 0 - 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; hydroxylamine; silver benzoate; sodium carbonate; caesium carbonate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: silver benzoate; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 16 h / Inert atmosphere; Reflux
3.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere; Reflux
3.2: 12 h / Reflux
4.1: hydroxylamine / water; methanol / 0.17 h / 0 °C / Inert atmosphere
4.2: 2.5 h / 0 - 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydroxylamine; silver benzoate; sodium carbonate; caesium carbonate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;