3-bromophenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 3-bromophenyl trifluoromethanesulfonate
• CAS No.: 66107-31-1
• Molecular Formula: C₇H₄BrF₃O₃S
• Molecular Weight: 305.072
• Mol file: 66107-31-1.mol

Synonyms:3-bromophenyl trifluoromethanesulfonate

Chemical Property of 3-bromophenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromophenyl trifluoromethanesulfonate

There total 1 articles about 3-bromophenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-Bromophenol (591-20-8) → 3-bromophenyl trifluoromethanesulfonate (66107-31-1)

Guidance literature:

With triethylamine; In dichloromethane; at -70 - 20 ℃; for 12h;

DOI:10.1002/anie.201609635

Reference yield: 99.0%

phenylethynylmagnesium bromide (6738-06-3) + 3-bromophenyl trifluoromethanesulfonate (66107-31-1) → 1-phenyl-2-(m-bromo)phenylacetylene (29778-29-8)

Guidance literature:

With dichloro<(2-dimethylamino)propyldiphenylphosphine>palladium; lithium bromide; In diethyl ether; toluene; at 20 ℃; for 1h;

DOI:10.1021/jo981191f

Reference yield: 94.0%

(2-methyl-2-phenylpropyl)zinc chloride + 3-bromophenyl trifluoromethanesulfonate (66107-31-1) → 3-(2-methyl-2-phenylpropyl)phenyl trifluoromethanesulfonate

Guidance literature:

With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In tetrahydrofuran; toluene; at 20 ℃; for 0.0833333h; chemoselective reaction;

DOI:10.1002/anie.201701691

upstream raw materials:

trifluoromethylsulfonic anhydride

3-Bromophenol

Downstream raw materials:

(3-bromo-phenyl)phosphonic acid diethyl ester

1,3-diphenylbenzene

3-bromobiphenyl

1-phenyl-2-(m-bromo)phenylacetylene

Refernces

• 1、 Kalvet, Indrek,Magnin, Guillaume,Schoenebeck, Franziska. "Rapid Room-Temperature, Chemoselective Csp2?Csp2Coupling of Poly(pseudo)halogenated Arenes Enabled by Palladium(I) Catalysis in Air". supporting information. p. 1581 - 1585. Retrieved 2017/02/05.
• 2、 Espino, Gustavo,Kurbangalieva, Almira,Brown, John M.. "Aryl bromide/triflate selectivities reveal mechanistic divergence in palladium-catalysed couplings; the Suzuki-Miyaura anomaly". . p. 1742 - 1744. Retrieved 2008/02/04.